ArticleRadiology2009
Tracheomalacia in adults with cystic fibrosis: determination of prevalence and severity with dynamic cine CT.
Article in Radiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Exercise and large airway issues.Physiological reports · 2025Review
- Tracheobronchomalacia is common in children with primary ciliary dyskinesia-A case note review.Pediatric pulmonology · 2024Article
- Prevalence and Determinants of Wheezing and Bronchodilatation in Children With Cystic Fibrosis: A Retrospective Cohort Study.Frontiers in pediatrics · 2022Article
- Left Main Bronchus Stenosis Lesion, Neutrophil Count, and Platelet Count Are Predictors of Post-Tuberculosis Bronchomalacia.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Detection and diagnosis of large airway collapse: a systematic review.ERJ open research · 2021Review
- Successful biodegradable stent insertion in an infant with severe bronchomalacia and cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2021Article
- The Strain on Airway Smooth Muscle During a Deep Inspiration to Total Lung Capacity.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- Review
- Is bronchoscopy an obsolete tool in cystic fibrosis? The role of bronchoscopy in cystic fibrosis and its clinical use.Journal of thoracic disease · 2017Review
- Sonographic evidence of abnormal tracheal cartilage ring structure in cystic fibrosis.The Laryngoscope · 2015Article
- What did we learn from two decades of chest computed tomography in cystic fibrosis?Pediatric radiology · 2014Review
- Tracheomalacia is associated with lower FEV1 and Pseudomonas acquisition in children with CF.Pediatric pulmonology · 2014Article
- Stridor and respiratory failure due to tracheobronchomalacia: case report and review of the literature.Sao Paulo medical journal = Revista paulista de medicina · 2012Review
- Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children.American journal of respiratory and critical care medicine · 2010Article
- Tracheobronchomalacia causing end expiratory grunt post-intubation.Anaesthesia reportsArticle
Corrections and comments
- Commented on by
- Erratum issuedTracheomalacia in Adults with Cystic Fibrosis: Determination of Prevalence and Severity with Dynamic Cine CT.2015 · Judge, Eoin E [corrected to Judge, Eoin P]
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the prevalence and severity of tracheomalacia in adults with cystic fibrosis (CF) by using dynamic cine multidetector computed tomography (CT) and to correlate these findings with pulmonary function test (PFT) results and the severity of parenchymal lung disease. MATERIALS AND
methodsIn this institutional review board-approved HIPAA-compliant study, 40 patients with CF (22 men, 18 women; mean age, 28 years +/- 8 [standard deviation]; age range, 18-54 years) prospectively underwent PFTs, standard thin-section CT, and two dynamic cine multidetector CT acquisitions. Ten control subjects underwent dynamic cine multidetector CT. After standard thin-section CT was completed, dynamic cine multidetector CT was performed during a forced expiratory maneuver and during coughing. Dynamic cine multidetector CT images in nine patients were excluded. Maximal inspiratory, dynamic expiratory, and end-expiratory tracheal luminal areas were compared (Student t test) and correlated (Spearman rank) with PFT results and severity of parenchymal lung disease.
resultsMean predicted forced expiratory volume in 1 second (FEV(1)) was 70.6% +/- 20.7, and mean Bhalla CT score was 41.8% +/- 13.6. In patients with CF, dynamic cine mean tracheal cross-sectional area reduction was 51.7% +/- 18.4 (range, 9%-89%) for forced expiratory maneuvers and 68.8% +/- 11.7 (range, 18%-88%) for coughing (P = .001). Tracheomalacia was demonstrated in 24 (69%) patients and no control subjects during forced expiratory maneuvers (P = .001) and in 10 (29%) patients and one (10%) control subject during coughing. For end-expiration images, mean tracheal luminal reduction was 16.1% +/- 14.0% (range, 0.0%-53.0%), with one patient demonstrating tracheal luminal reduction of more than 50%. There was no correlation between tracheal cross-sectional luminal reduction and either predicted FEV(1) or CT Bhalla score.
conclusionTracheomalacia depicted at dynamic cine multidetector CT is a highly prevalent finding in adults with CF. SUPPLEMENTAL MATERIAL: http://radiology.rsnajnls.org/cgi/content/full/2522081956/DC1.
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