ArticleBritish journal of pharmacology2009
Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, alpha- and beta-amyrin, in a mouse model of colitis.
Article in British journal of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 94 citations in OpenAlex.
- Article
- Article
- Terpenes: Modulating anti-inflammatory signaling in inflammatory bowel disease.Pharmacology & therapeutics · 2023Review
- Phytochemical and Ethnopharmacological Perspectives ofMolecules (Basel, Switzerland) · 2021Review
- Structural elucidation and in vivo anti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae).Bioorganic chemistry · 2020Article
- Saussurea lappa root extract ameliorates the hazards effect of thorium induced oxidative stress and neuroendocrine alterations in adult male rats.Environmental science and pollution research international · 2020Article
- Effects of Aqueous and Methanolic Extracts of Stem Bark ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Cannabis, Cannabinoids, and the Endocannabinoid System-Is there Therapeutic Potential for Inflammatory Bowel Disease?Journal of Crohn's & colitis · 2019Review
- Antinociceptive and anti-inflammatory activities of a triterpene-rich fraction from Himatanthus drasticus.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Phytochemical Analysis ofMolecules (Basel, Switzerland) · 2018Article
- An Improved Scalable Synthesis of α- and β-Amyrin.Molecules (Basel, Switzerland) · 2018Article
- Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice.Neuroscience bulletin · 2017Article
- New ursane triterpenoids from Ficus pandurata and their binding affinity for human cannabinoid and opioid receptors.Archives of pharmacal research · 2016Article
- Bardoxolone Methyl Prevents High-Fat Diet-Induced Colon Inflammation in Mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Ethnopharmacological Significance of Eclipta alba (L.) Hassk. (Asteraceae).International scholarly research notices · 2014Review
- Antiinflammatory effect of phytosterols in experimental murine colitis model: prevention, induction, remission study.PloS one · 2014Article
- Triterpenoid resinous metabolites from the genus Boswellia: pharmacological activities and potential species-identifying properties.Chemistry Central journal · 2013Article
- Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice.Lipids in health and disease · 2012Article
- The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats.British journal of pharmacology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposealpha- and beta-amyrin are pentacyclic triterpenes found in plants and are known to exhibit pronounced anti-inflammatory effects. Here, we evaluated the effects of a 1:1 mixture of alpha- and beta-amyrin (alpha,beta-amyrin) on an experimental model of colitis in mice. EXPERIMENTAL APPROACH: Colitis was induced in Swiss male mice by trinitrobenzene sulphonic acid (TNBS) and followed up to 72 h; animals were treated systemically with alpha,beta-amyrin, dexamethasone or vehicle. Macro- and microscopic damage, myeloperoxidase activity and cytokine levels were assessed in colons. Histological sections were immunostained for cyclooxygenase-2 (COX-2), vascular endothelial growth factor, phospho-p65 nuclear factor-kappaB (NF-kappaB) and phospho-cyclic AMP response element-binding protein (CREB). KEY
resultsTNBS-induced colitis was associated with tissue damage, neutrophil infiltration and time-dependent increase of inflammatory mediators. Treatment with alpha,beta-amyrin (3 mg x kg(-1), i.p.) or dexamethasone (1 mg x kg(-1), s.c.) consistently improved tissue damage scores and abolished polymorphonuclear cell infiltration. alpha,beta-Amyrin, like dexamethasone, significantly diminished interleukin (IL)-1beta levels and partially restored IL-10 levels in colon tissues 72 h after colitis induction, but only alpha,beta-amyrin reduced vascular endothelial growth factor expression by immunohistochemistry. The colonic expression of COX-2 at 24 h and that of phospho-NF-kappaB and phospho-CREB (peaking at 6 h) after colitis induction were consistently inhibited by both alpha,beta-amyrin and dexamethasone. CONCLUSIONS AND IMPLICATIONS: Systemic administration of alpha,beta-amyrin exerted a marked and rapid inhibition of TNBS-induced colitis, related to the local suppression of inflammatory cytokines and COX-2 levels, possibly via inhibition of NF-kappaB and CREB-signalling pathways. Taken together, our data suggest a potential use of alpha,beta-amyrin to control inflammatory responses in bowel disease.
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