ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2009
Host-related risk factors and clinical features of community-acquired legionnaires disease due to the Paris and Lorraine endemic strains, 1998-2007, France.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Review Global seroprevalence of legionellosis - a systematic review and meta-analysis.Scientific reports · 2020Pooled it
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- Bacterial persistence inFrontiers in cellular and infection microbiology · 2023Article
- TNF-α response in macrophages depends on clinicalVirulence · 2022Article
- Legionella Pneumonia Following the Heavy Rain Event of July 2018 in Japan.Internal medicine (Tokyo, Japan) · 2019Article
- Legionnaires' disease as an occupational risk related to decontamination work after the Fukushima nuclear disaster: A case report.Journal of occupational health · 2018Article
- Short-term effects of atmospheric pressure, temperature, and rainfall on notification rate of community-acquired Legionnaires' disease in four European countries.Epidemiology and infection · 2016Article
- Complex clinical and microbiological effects on Legionnaires' disease outcone; A retrospective cohort study.BMC infectious diseases · 2016Article
- Legionella pneumophila Seropositivity-Associated Factors in Latvian Blood Donors.International journal of environmental research and public health · 2015Article
- Epidemiologic characteristics associated with ST23 clones compared to ST1 and ST47 clones of Legionnaires disease cases in France.New microbes and new infections · 2015Article
- Necessity and effect of combating Legionella pneumophila in municipal shower systems.PloS one · 2014Article
- Lcl of Legionella pneumophila is an immunogenic GAG binding adhesin that promotes interactions with lung epithelial cells and plays a crucial role in biofilm formation.Infection and immunity · 2011Article
- Legionella pneumophila goes clonal--Paris and Lorraine strain-specific risk factors.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009Article
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Abstract
backgroundIn France, Legionnaires disease is mainly caused by Legionella pneumophila. Here, we investigated possible host factors associated with susceptibility to community-acquired Legionnaires disease caused by the endemic Paris and Lorraine strains.
methodsWe conducted a double-nested exploratory case-control study with use of data from the French national surveillance network of incident Legionnaires disease cases notified from 1998 through 2007. Patients with community-acquired Legionnaires disease and an L. pneumophila serogroup 1 isolate were eligible. Case patients were patients infected by the Paris or Lorraine strain, and control patients were those infected by sporadic strains. Epidemiological and clinical factors associated with infection with the Paris and Lorraine strains were assessed by calculating adjusted odds ratios (aOR) in multivariate logistic regression models.
resultsWe studied 1090 patients infected by sporadic strains (n = 920), the Paris strain (n = 80), or the Lorraine strain (n = 90). Infection with the Paris strain was significantly associated with female sex (aOR, 1.98; 95% confidence interval [CI], 1.19-3.28), steroid therapy (aOR, 3.16; 95% CI, 1.76-5.68), and a history of cancer or hematologic malignancies (aOR, 2.08; 95% CI, 1.15-3.76). In addition, the mortality rate was higher among patients infected with the Paris strain than in the control group (38% vs. 25.5%). The Lorraine strain was associated with smoking (aOR, 1.82; 95% CI, 1.14-2.91) and reduced mortality (9.9%). .
conclusionSeveral host characteristics were associated with the risk of infection by endemic strains of L. pneumophila serogroup 1. These findings may help to guide preventive measures. Factors predisposing patients to infection by specific strains need to be explored further.
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