ArticleThe Journal of the Acoustical Society of America2009
Characterization of the trabecular bone structure using frequency modulated ultrasound pulse.
Article in The Journal of the Acoustical Society of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Space exploration as a catalyst for medical innovations.Frontiers in medicine · 2023Article
- Mechanisms of Interaction of Ultrasound With Cancellous Bone: A Review.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Review
- Nonlinear attenuation and dispersion in human calcaneus in vitro: statistical validation and relationships to microarchitecture.The Journal of the Acoustical Society of America · 2015Article
- The application of backscattered ultrasound and photoacoustic signals for assessment of bone collagen and mineral contents.Quantitative imaging in medicine and surgery · 2015Article
- Frequency specific ultrasound attenuation is sensitive to trabecular bone structure.Ultrasound in medicine & biology · 2012Article
- Role of structural anisotropy of biological tissues in poroelastic wave propagation.Mechanics of materials : an international journal · 2012Article
- Effects of phase cancellation and receiver aperture size on broadband ultrasonic attenuation for trabecular bone in vitro.Ultrasound in medicine & biology · 2011Article
- Evaluation of a pulsed phase-locked loop system for noninvasive tracking of bone deformation under loading with finite element and strain analysis.Physiological measurement · 2011Article
- Article
- Fabric dependence of quasi-waves in anisotropic porous media.The Journal of the Acoustical Society of America · 2011Article
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Authors and funding
3 authors.
Funding
Abstract
The objective of this study was to investigate the efficacy of modulated ultrasound signals in the measurement of bone properties as an early indicator of osteoporosis. Twenty-one trabecular bone cubes were harvested from sheep femoral condyles and the cube axes corresponded to the anatomic superior-inferior (SI), antero-posterior (AP), and medio-lateral (ML) orientations. Micro-CT measurements were made on those samples to obtain bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular separation (Tb.Sp). Ultrasound tests were performed in the three orthogonal orientations using pulse and frequency modulated ultrasound. The comparison of the frequency modulated attenuation (FMA) with the broadband ultrasound attenuation (BUA) was made within the frequency band between 300 and 700 kHz. Results showed that FMA demonstrated higher correlations to the trabecular structure properties in the SI orientation (R(2)=0.84 for BV/TV, R(2)=0.77 for Tb.Th, R(2)=0.7 for Tb.Sp) than BUA (R(2)=0.30 for BV/TV, R(2)=0.27 for Tb.Th, R(2)=0.33 for Tb.Sp). In the AP orientation, FMA had higher correlation to Tr.Sp (R(2)=0.64) than BUA (R(2)=0.48), and relatively lower correlation to BV/TV (R(2)=0.48) and Tb.Th (R(2)=0.31) than BUA (R(2)=0.64 for BV/TV and R(2)=0.58 for Tb.Th). The results suggested that FMA could be a new ultrasound index for bone properties assessment.
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