ArticleHuman brain mapping2009
Relation between brain lesion location and clinical outcome in patients with severe traumatic brain injury: a diffusion tensor imaging study using voxel-based approaches.
Article in Human brain mapping, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Diffusion tensor imaging studies of mild traumatic brain injury: a meta-analysis.Journal of neurology, neurosurgery, and psychiatry · 2012Pooled it
- Differences in the Subcortical White Matter Integrity Based on the Disorder of Consciousness at the Chronic Stage of Diffuse Axonal Injury: A Tract-Based Spatial Statistics Study.Medicina (Kaunas, Lithuania) · 2026Article
- White matter connectometry in patients with disorders of consciousness revealed by 7-Tesla magnetic resonance imaging.Brain imaging and behavior · 2022Article
- Prognostic value of global deep white matter DTI metrics for 1-year outcome prediction in ICU traumatic brain injury patients: an MRI-COMA and CENTER-TBI combined study.Intensive care medicine · 2022Article
- White Matter Abnormalities in Traumatic Subarachnoid Hemorrhage: A Tract-Based Spatial Statistics Study.Medical science monitor : international medical journal of experimental and clinical research · 2021Observational
- Reliability of the freehand region-of-interest method in quantitative cerebral diffusion tensor imaging.BMC medical imaging · 2021Article
- Lesion Normalization and Supervised Learning in Post-traumatic Seizure Classification with Diffusion MRI.Computational diffusion MRI. CDMRI (Workshop) · 2021Article
- Comparison of season-long diffusivity measures in a cohort of non-concussed contact and non-contact athletes.Journal of clinical and experimental neuropsychology · 2020Article
- Neuroimage-Based Consciousness Evaluation of Patients with Secondary Doubtful Hydrocephalus Before and After Lumbar Drainage.Neuroscience bulletin · 2020Article
- Neural Connectivity Changes Facilitated by Familiar Auditory Sensory Training in Disordered Consciousness: A TBI Pilot Study.Frontiers in neurology · 2020Article
- Association between tumor location and neurocognitive functioning using tumor localization maps.Journal of neuro-oncology · 2019Observational
- Brain Network Studies in Chronic Disorders of Consciousness: Advances and Perspectives.Neuroscience bulletin · 2018Review
- Subdivisions of the posteromedial cortex in disorders of consciousness.NeuroImage. Clinical · 2018Article
- Revisiting Grade 3 Diffuse Axonal Injury: Not All Brainstem Microbleeds are Prognostically Equal.Neurocritical care · 2017Article
- DTI measures identify mild and moderate TBI cases among patients with complex health problems: A receiver operating characteristic analysis of U.S. veterans.NeuroImage. Clinical · 2017Article
- Predictors of Recovery from Traumatic Brain Injury-Induced Prolonged Consciousness Disorder.Neural plasticity · 2017Article
- White Matter Changes in Posttraumatic Stress Disorder Following Mild Traumatic Brain Injury: A Prospective Longitudinal Diffusion Tensor Imaging Study.Chinese medical journal · 2016Article
- Mapping the Connectome Following Traumatic Brain Injury.Current neurology and neuroscience reports · 2016Review
- Traumatic Brain Injury as a Disorder of Brain Connectivity.Journal of the International Neuropsychological Society : JINS · 2016Review
- Diffusion tensor imaging in acute-to-subacute traumatic brain injury: a longitudinal analysis.BMC neurology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early prediction of consciousness recovery from traumatic brain injury (TBI) is crucial to make decisions about the appropriate use of prolonged intensive care. Diffusion tensor imaging (DTI) has been proposed as a biomarker of white matter injury that could be used in a classification purpose. Instead of region-of-interest-based approach, we applied voxel-based approaches (voxel-based DTI and tract-based spatial statistics) on 30 patients with TBI to identify, without any prior, the brain regions that were specifically damaged in unfavorable 1-year outcome group compared to the favorable one. DTI were acquired at mean 23 days (5-53 days) and two DTI-derived indices, fractional anisotropy (FA) and apparent diffusion coefficient (ADC), were tested. Our results showed that (1) ADC is not a relevant biomarker for early 1-year outcome prognosis; (2) FA measured in inferior longitudinal fasciculus, in cerebral peduncle, in posterior limb of the internal capsule, and in posterior corpus callosum is specifically decreased in unfavorable outcome group compare to the favorable one; (3) a linear discriminant analysis using the FA measured in these four regions showed good classification performance (sensitivity = 86% and specificity = 86%). These findings confirm the relevance of the use of DTI as biomarkers for consciousness recovery after TBI and support the possible use of these biomarkers for early classification of patients.
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