ArticleAge (Dordrecht, Netherlands)2009
Thymopoiesis in elderly human is associated with systemic inflammatory status.
Article in Age (Dordrecht, Netherlands), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 62 citations in OpenAlex.
- Age-associated changes in innate and adaptive immunity: role of the gut microbiota.Frontiers in immunology · 2024Review
- Neutrophil-Mediated Progression of Mild Cognitive Impairment to Dementia.International journal of molecular sciences · 2023Review
- Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipients.Frontiers in immunology · 2023Article
- Exploiting Signal Joint T Cell Receptor Excision Circle to Investigate the Impact of COVID-19 and Autoimmune Diseases on Age Prediction and Immunosenescence.Biomedicines · 2022Article
- Baseline lymphopenia as prognostic factor in patients with metastatic breast cancer treated with palbociclib.Oncology letters · 2022Article
- Pretreatment neutrophil to lymphocyte ratio as prognostic factor in metastatic breast cancer treated with cyclin dependent kinase 4/6 inhibitors.Frontiers in oncology · 2022Article
- Article
- Coronavirus Disease (COVID-19): A Perspective from Immunosenescence.Aging and disease · 2021Article
- Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators.Brain : a journal of neurology · 2020Article
- Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling.Frontiers in immunology · 2020Article
- Baseline Lymphopenia: A Predictor Of Poor Outcomes In HER2 positive Metastatic Breast Cancer Treated With Trastuzumab.Drug design, development and therapy · 2019Article
- Development of Immature CD4Frontiers in cell and developmental biology · 2019Article
- The Great Recession and Immune Function.The Russell Sage Foundation journal of the social sciences : RSF · 2018Article
- Thymic Function Failure Is Associated With Human Immunodeficiency Virus Disease Progression.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy.Immunity & ageing : I & A · 2016Article
- Population Distributions of Thymic Function in Adults: Variation by Sociodemographic Characteristics and Health Status.Biodemography and social biology · 2016Article
- WNT signaling suppression in the senescent human thymus.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- First line palliative chemotherapy in elderly patients with advanced soft tissue sarcoma.Clinical sarcoma research · 2015Article
- Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans.Age (Dordrecht, Netherlands) · 2013Article
- Lymphopenia combined with low TCR diversity (divpenia) predicts poor overall survival in metastatic breast cancer patients.Oncoimmunology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunosenescence studies of age-related immune system damage focused on clinical lymphopenic situations or androgenic blockade have revealed new insights about adult human immune reconstitution. However, as far as we know, the extent of lymphopoiesis in the thymus of elderly humans remains unclear. To this effect, we have analyzed 65 adult human thymuses (from 36 to 81 years; median age 68.6 years) obtained from patients who underwent cardiac surgery. Our results show a correlation between CD4(+)CD8(+) double-positive (DP) cells and both the age (inverse) and percentage (direct) of peripheral naive T cells, indicating that the thymus is still able to affect the peripheral lymphocyte pool even in the elderly. We also found significant correlation between the degree of thymopoiesis and the inflammation markers, as shown by the inverse correlations between DP and the percentage of neutrophils and IL-6 levels and the percentage of peripheral lymphocytes. Furthermore, in a multivariate linear regression the percentage of DP and IL-7 levels, but not age, were independently associated with the percentage of neutrophils. In conclusion, the thymus maintains, even in the elderly, an active thymopoiesis that rejuvenates the peripheral naive T-cell pool. Moreover, age-related thymopoietic decay is associated with the peripheral inflammation markers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.