ArticleInflammation2009
Potassium humate inhibits complement activation and the production of inflammatory cytokines in vitro.
Article in Inflammation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 48 citations in OpenAlex.
- Pharmacological Effects of Humic Substances and Their Signaling Mechanisms.Molecules (Basel, Switzerland) · 2025Review
- Humic substances from composted fennel residues control the inflammation induced by Helicobacter pylori infection in AGS cells.PloS one · 2023Article
- Protective Roles of Shilajit in Modulating Resistin, Adiponectin, and Cytokines in Rats with Non-alcoholic Fatty Liver Disease.Chinese journal of integrative medicine · 2022Article
- Modification of the chemically induced inflammation assay reveals the Janus face of a phenol rich fulvic acid.Scientific reports · 2022Article
- Antiflammatory activity and potential dermatological applications of characterized humic acids from a lignite and a green compost.Scientific reports · 2022Article
- Anti-Allergic Properties of Humic Acids Isolated from Pine-Sphagnum-Cotton Sedge Peat.Bulletin of experimental biology and medicine · 2022Article
- Effective Doses of Ionizing Radiation during Therapeutic Peat Mud Treatment from a Deposit in the Knyszyn Forest (Northeastern Poland).International journal of environmental research and public health · 2020Article
- Microwave-Assisted Synthesis of Water-Dispersible Humate-Coated Magnetite Nanoparticles: Relation of Coating Process Parameters to the Properties of Nanoparticles.Nanomaterials (Basel, Switzerland) · 2020Article
- Effect of the Addition of Humic Substances as Growth Promoter in Broiler Chickens Under Two Feeding Regimens.Animals : an open access journal from MDPI · 2019Article
- The effects of humic water on endothelial cells under hyperglycemic conditions: inflammation-associated parameters.Environmental geochemistry and health · 2019Article
- Potassium humate inhibits carrageenan-induced paw oedema and a graft-versus-host reaction in rats.Inflammopharmacology · 2010Article
- The effect of combining humic and fulvic acids poultice on wound healing in male rats.Journal of cutaneous and aesthetic surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of brown coal derived potassium humate on lymphocyte proliferation, cytokine production and complement activation were investigated in vitro. Potassium humate increased lymphocyte proliferation of phytohaemaglutinin A (PHA) and pokeweed mitogen (PWM) stimulated mononuclear lymphocytes (MNL) in vitro from concentrations of 20 to 80 microg/ml, in a dose dependant manner. On the other hand potassium humate, at 40 microg/ml, significantly inhibited the release of TNF-alpha, IL-1beta, IL-6 and IL-10 by PHA stimulated MNL. Regarding complement activation it was found that potassium humate inhibits the activation of both the alternative and classical pathways without affecting the stability of the red blood cell membranes. These results indicate that the anti-inflammatory potential of potassium humate could be partially due to the inhibition of pro-inflammatory cytokines responsible for the initiation of these reactions as well as inhibition of complement activation. The increased lymphocyte proliferation observed, might be due to increased IL-2 production as previously been documented.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.