Trial reportAnnals of surgical oncology2009
Contralateral prophylactic mastectomy for unilateral breast cancer: an increasing trend at a single institution.
Trial report in Annals of surgical oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Deimplementation of the Choosing Wisely Recommendations for Low-Value Breast Cancer Surgery: A Systematic Review.JAMA surgery · 2020Pooled it
- Risk-reducing mastectomy for the prevention of primary breast cancer.The Cochrane database of systematic reviews · 2018Pooled it
- Contralateral prophylactic mastectomy after unilateral breast cancer: a systematic review and meta-analysis.Annals of surgery · 2014Pooled it
- B-Sure: a randomized pilot trial of an interactive web-based decision support aid versus usual care in average-risk breast cancer patients considering contralateral prophylactic mastectomy.Translational behavioral medicine · 2020Trial
- Trial
- Understanding Patient Decision-Making in Breast Cancer Surgery: Risk Perception, Communication, and Psychosocial Influences.Medical sciences (Basel, Switzerland) · 2025Article
- Body Weight and Breast Cancer Treatment Experiences: Results From the Share Thoughts on a Breast Cancer Study.Cancer medicine · 2025Article
- Trends in utilization of contralateral prophylactic mastectomy among different age, racial and ethnic groups.Gland surgery · 2023Article
- Timely cancer genetic counseling and testing for young women with breast cancer: impact on surgical decision-making for contralateral risk-reducing mastectomy.Breast cancer research and treatment · 2022Article
- Laterality and Patient-Reported Outcomes following Autologous Breast Reconstruction with Free Abdominal Tissue: An 8-Year Examination of BREAST-Q Data.Plastic and reconstructive surgery · 2020Article
- Barriers and Facilitators to De-Implementation of the Choosing WiselyAnnals of surgical oncology · 2020Article
- Axillary management for young women with breast cancer varies between patients electing breast-conservation therapy or mastectomy.Breast cancer research and treatment · 2020Article
- Volumetric Symmetry after Unilateral Autologous Breast Reconstruction: A Reasonable Goal.Plastic and reconstructive surgery. Global open · 2019Article
- Two-Staged Implant-Based Breast Reconstruction: A Long-Term Outcome Study in a Young Population.Medicina (Kaunas, Lithuania) · 2019Article
- The use of contralateral prophylactic mastectomy among elderly patients in the United States.Breast cancer research and treatment · 2019Article
- Decisional conflict among breast cancer patients considering contralateral prophylactic mastectomy.Patient education and counseling · 2019Article
- Surgical Outcomes of Prepectoral Versus Subpectoral Implant-based Breast Reconstruction in Young Women.Plastic and reconstructive surgery. Global open · 2019Article
- Contralateral prophylactic mastectomy in young women with breast cancer: a population-based analysis of predictive factors and clinical impact.Current oncology (Toronto, Ont.) · 2018Article
- Surgical Management of Lobular Carcinoma In Situ: Analysis of the National Cancer Database.Annals of surgical oncology · 2018Article
- Contralateral prophylactic mastectomy rate and predictive factors among patients with breast cancer who underwent multigene panel testing for hereditary cancer.Cancer medicine · 2018Article
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn increasing trend in the use of contralateral prophylactic mastectomy (CPM) for the treatment of unilateral breast cancer has been observed nationally. The purpose of this study was to confirm this trend and to identify differences between the groups that chose unilateral mastectomy alone or with CPM.
methodsA prospectively maintained breast cancer database was retrospectively reviewed. Age, histologic grade, stage, education, family history, tumor receptor status, and use of immediate reconstruction were evaluated. Statistical analysis was performed by Fisher's exact test, chi(2) test, and Student's t-test.
resultsBetween 1998 and 2007, a total of 1639 women who selected UM and 201 who had UM and CPM for unilateral breast cancer were identified. An increasing trend in CPM was observed (6.5% in 1999 vs. 16.1% in 2007). The CPM group was significantly younger (mean age 47.8 vs. 55.1 years, P < .001). No difference in histologic grade was noted between the two groups; however, an increasing trend toward CPM was observed with lower-stage disease. Women with a higher educational level were more likely to have CPM (P < .001). Women with a family history of cancer were also more likely to have CPM (57% vs. 41%, P < .001). Use of reconstruction was similar between the groups (6.0% for CPM vs. 6.7% for UM, P = NS).
conclusionsOur experience parallels the national trend of increasing use of CPM in women diagnosed with unilateral breast cancer. Women who chose to have CPM were younger, more highly educated, and more likely to have a family history of cancer.
Indexed as
Identifiers
19506956What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.