ArticleEuropean biophysics journal : EBJ2010
Structural implications of mutations assessed by molecular dynamics: Vpu1-32 from HIV-1.
Article in European biophysics journal : EBJ, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Structure based computational assessment of channel properties of assembled ORF-8a from SARS-CoV.Proteins · 2015Article
- Molecular dynamics simulations reveal the HIV-1 Vpu transmembrane protein to form stable pentamers.PloS one · 2013Article
- Viral channel forming proteins - modeling the target.Biochimica et biophysica acta · 2011Review
- Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity.PloS one · 2011Article
- HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms.Molecular aspects of medicine · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structural pore models are generated for Vpu(1-32)WT from HIV-1 as well as for three mutants W23L, S24L and R31V. A computational methodology is employed which samples the whole conformational space of the pentameric assemblies of Vpu. The analysis of the related energy landscape reveals a small set of reasonable pore models, which are thoroughly investigated regarding their structural properties as well as their putative stability under native-like conditions. The models are also discussed in respect of earlier experimental findings about their channel activities. The study proposes functional pores reflecting the experimentally found conductance states of Vpu and its mutants.
Indexed as
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19506851What OpenQuestion holds
Registered trials
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