ArticlePhysical chemistry chemical physics : PCCP2009
Motor-induced sliding of microtubule and actin bundles.
Article in Physical chemistry chemical physics : PCCP, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Comparative profiling of cellular gait on adhesive micropatterns defines statistical patterns of activity that underlie native and cancerous cell dynamics.bioRxiv : the preprint server for biology · 2023Article
- Article
- Mechanical Regulation of Neurite Polarization and Growth: A Computational Study.Biophysical journal · 2020Article
- Article
- A Mechanistic View of Collective Filament Motion in Active Nematic Networks.Biophysical journal · 2020Article
- Remarkable structural transformations of actin bundles are driven by their initial polarity, motor activity, crosslinking, and filament treadmilling.PLoS computational biology · 2019Article
- Emergent mechanics of actomyosin drive punctuated contractions and shape network morphology in the cell cortex.PLoS computational biology · 2018Article
- Polarity Sorting of Microtubules in the Axon.Trends in neurosciences · 2018Review
- Enhanced Dynamics of Confined Cytoskeletal Filaments Driven by Asymmetric Motors.Biophysical journal · 2017Article
- Modeling molecular mechanisms in the axon.Computational mechanics · 2017Article
- Actomyosin contraction, aggregation and traveling waves in a treadmilling actin array.Physica D. Nonlinear phenomena · 2016Article
- Architecture and Connectivity Govern Actin Network Contractility.Current biology : CB · 2016Article
- A Combination of Actin Treadmilling and Cross-Linking Drives Contraction of Random Actomyosin Arrays.Biophysical journal · 2015Article
- Force Generation by Molecular-Motor-Powered Microtubule Bundles; Implications for Neuronal Polarization and Growth.Frontiers in cellular neuroscience · 2015Article
- Multiscale modeling and simulation of microtubule-motor-protein assemblies.Physical review. E, Statistical, nonlinear, and soft matter physics · 2015Article
- The value of mechanistic biophysical information for systems-level understanding of complex biological processes such as cytokinesis.Biophysical journal · 2014Review
- Force to divide: structural and mechanical requirements for actomyosin ring contraction.Biophysical journal · 2013Review
- Stress generation by myosin minifilaments in actin bundles.Physical biology · 2013Article
- Mathematical modeling of eukaryotic cell migration: insights beyond experiments.Annual review of cell and developmental biology · 2013Review
- Actin depolymerization drives actomyosin ring contraction during budding yeast cytokinesis.Developmental cell · 2012Article
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Authors and funding
2 authors.
Funding
Abstract
Interactions of multiple molecular motors with bundles of actin and microtubule filaments form the basis for many cytoskeletal processes including axonal growth, muscle contraction, cell division and platelet formation. Continuum models based on generalized diffusion equations have been suggested to quantify the dynamics of such active bundles. In highly cross-linked and densely packed filament bundles, however, a major complication arises due to the multiple interactions that each filament forms with its neighbors. To explore the effects of these interactions, we used detailed computer simulations and studied the bundles with different types of motors at different densities and boundary conditions. We found that highly cross-linked bundles exhibit effects of long-ranged interactions that are sensitive to the boundary conditions. In open bundles, these give rise to 'telescopic' patterns resulting in significant acceleration of the filaments at the edges. In contrast, in ringed bundles, the long-ranged interactions 'lock' filaments and slow down their movements. The filaments in loosely connected bundles, on the other hand, undergo local diffusion-drift dynamics consistent with previous continuum models. Our simulations also demonstrate the sorting phenomena in the mixed-polarity bundles and reveal characteristic scales and conditions for spontaneous pattern formation in the bundle. We discuss the relevance of our results for cytoskeleton systems such as microtubules in axons, platelet formation, kinetochore fibers and actin bundles in motile cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.