ArticleCurrent genomics2008
Molecular cytogenetics and cytogenomics of brain diseases.
Article in Current genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed.
- Review
- Cytogenomic epileptology.Molecular cytogenetics · 2023Review
- Svetlana G. Vorsanova (1945-2021).Molecular cytogenetics · 2022Article
- Systems Cytogenomics: Are We Ready Yet?Current genomics · 2021Article
- Review
- Cytopostgenomics: What is it and how does it work?Current genomics · 2019Article
- Pathway-based classification of genetic diseases.Molecular cytogenetics · 2019Article
- What Is Karyotype Coding and Why Is Genomic Topology Important for Cancer and Evolution?Frontiers in genetics · 2019Review
- The variome concept: focus on CNVariome.Molecular cytogenetics · 2019Article
- The X Files: "The Mystery of X Chromosome Instability in Alzheimer's Disease".Frontiers in genetics · 2019Review
- Mosaic Brain Aneuploidy in Mental Illnesses: An Association of Low-level Post-zygotic Aneuploidy with Schizophrenia and Comorbid Psychiatric Disorders.Current genomics · 2018Review
- Behavioral Variability and Somatic Mosaicism: A Cytogenomic Hypothesis.Current genomics · 2018Review
- 4q21.2q21.3 Duplication: Molecular and Neuropsychological Aspects.Current genomics · 2018Review
- Retrotransposing Gremlins May Disrupt Our Brain's Genomes.Molecular syndromology · 2017Article
- 3p22.1p21.31 microdeletion identifies CCK as Asperger syndrome candidate gene and shows the way for therapeutic strategies in chromosome imbalances.Molecular cytogenetics · 2015Article
- Assessment of copy number variations in the brain genome of schizophrenia patients.Molecular cytogenetics · 2015Article
- Long contiguous stretches of homozygosity spanning shortly the imprinted loci are associated with intellectual disability, autism and/or epilepsy.Molecular cytogenetics · 2015Article
- Potential epigenetic mechanism(s) associated with the persistence of psychoneurological symptoms in women receiving chemotherapy for breast cancer: a hypothesis.Biological research for nursing · 2014Article
- X chromosome aneuploidy in the Alzheimer's disease brain.Molecular cytogenetics · 2014Article
- An interstitial deletion at 10q26.2q26.3.Case reports in genetics · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular cytogenetics is a promising field of biomedical research that has recently revolutionized our thinking on genome structure and behavior. This is in part due to discoveries of human genomic variations and their contribution to biodiversity and disease. Since these studies were primarily targeted at variation of the genome structure, it appears apposite to cover them by molecular cytogenomics. Human brain diseases, which encompass pathogenic conditions from severe neurodegenerative diseases and major psychiatric disorders to brain tumors, are a heavy burden for the patients and their relatives. It has been suggested that most of them, if not all, are of genetic nature and several recent studies have supported the hypothesis assuming them to be associated with genomic instabilities (i.e. single-gene mutations, gross and subtle chromosome imbalances, aneuploidy). The present review is focused on the intriguing relationship between genomic instability and human brain diseases. Looking through the data, we were able to conclude that both interindividual and intercellular genomic variations could be pathogenic representing, therefore, a possible mechanism for human brain malfunctioning. Nevertheless, there are still numerous gaps in our knowledge concerning the link between genomic variations and brain diseases, which, hopefully, will be filled by forthcoming studies. In this light, the present review considers perspectives of this dynamically developing field of neurogenetics and genomics.
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