ArticleCurrent genomics2008
Molecular genetics of alcohol dependence and related endophenotypes.
Article in Current genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Preconceptional motivational interviewing interventions to reduce alcohol-exposed pregnancy risk.Journal of substance abuse treatment · 2013Trial
- Association between polygenic risk for tobacco or alcohol consumption and liability to licit and illicit substance use in young Australian adults.Drug and alcohol dependence · 2019Article
- Bipolar disorder and alcohol use disorder: a review.Current psychiatry reports · 2012Review
- Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
- Breaking barriers in the genomics and pharmacogenetics of drug addiction.Clinical pharmacology and therapeutics · 2010Review
- Genetic and environmental influences on ethanol consumption: perspectives from preclinical research.Alcoholism, clinical and experimental research · 2010Review
- Molecular basis and current treatment for alcoholic liver disease.International journal of environmental research and public health · 2010Review
- A new definition of early age at onset in alcohol dependence.Drug and alcohol dependence · 2010Article
- Suicidal behavior and alcohol abuse.International journal of environmental research and public health · 2010Article
- Changes in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking.Alcohol (Fayetteville, N.Y.) · 2010Article
- Genetic contribution to individual variation in binocular rivalry rate.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Pharmacotherapy for alcohol use disorder: current and emerging therapies.Harvard review of psychiatryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alcohol dependence is a worldwide public health problem, and involves both environmental and genetic vulnerability factors. The heritability of alcohol dependence is rather high, ranging between 50% and 60%, although alcohol dependence is a polygenic, complex disorder.Genome-wide scans on large cohorts of multiplex families, including the collaborative study on genetics of alcoholism (COGA), emphasized the role of many chromosome regions and some candidate genes. The genes encoding the alcohol-metabolizing enzymes, or those involved in brain reward pathways, have been involved. Since dopamine is the main neurotransmitter in the reward circuit, genes involved in the dopaminergic pathway represent candidates of interest. Furthermore, gamma-amino-butyric acid (GABA) neurotransmitter mediates the acute actions of alcohol and is involved in withdrawal symptomatology. Numerous studies showed an association between variants within GABA receptors genes and the risk of alcohol dependence.In accordance with the complexity of the "alcohol dependence" phenotype, another field of research, related to the concept of endophenotypes, received more recent attention. The role of vulnerability genes in alcohol dependence is therefore re-assessed focusing on different phenotypes and endophenotypes. The latter include brain oscillations, EEG alpha and beta variants and alpha power, and amplitude of P300 amplitude elicited from a visual oddball task.Recent enhancement on global characterizations of the genome by high-throughput approach for genotyping of polymorphisms and studies of transcriptomics and proteomics in alcohol dependence is also reviewed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.