ReviewNature reviews. Genetics2009
Challenges of translating genetic tests into clinical and public health practice.
Review in Nature reviews. Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Which Lynch syndrome screening programs could be implemented in the "real world"? A systematic review of economic evaluations.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Pooled it
- Public knowledge of and attitudes toward genetics and genetic testing.Genetic testing and molecular biomarkers · 2013Trial
- [Genomics in Public Health Scientific evidence and prospects for integration in the prevention practice].Journal of preventive medicine and hygiene · 2022Article
- Clinical outcomes and temporal trends of immunological and non-immunological rare diseases in adult kidney transplant.BMC nephrology · 2021Article
- A Focus Group Study of Perceptions of Genetic Risk Disclosure in Members of the Public in Sweden: "I'll Phone the Five Closest Ones, but What Happens to the Other Ten?"Journal of personalized medicine · 2021Article
- [The molecular tumor board].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Review
- How can Australia integrate routine genetic sequencing in oncology: a qualitative study through an implementation science lens.Genetics in medicine : official journal of the American College of Medical Genetics · 2020Article
- Bridging the Gaps in Personalized Medicine Value Assessment: A Review of the Need for Outcome Metrics across Stakeholders and Scientific Disciplines.Public health genomics · 2019Review
- The Evolution of Public Health Genomics: Exploring Its Past, Present, and Future.Frontiers in public health · 2018Review
- The economic case for precision medicine.Expert review of precision medicine and drug development · 2018Article
- Common Elements in Rare Kidney Diseases: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2017Article
- Risk Prediction Modeling on Family-Based Sequencing Data Using a Random Field Method.Genetics · 2017Article
- Drug Discovery Testing Compounds in Patient Samples by Automated Flow Cytometry.SLAS technology · 2017Article
- Health regulatory communications of well-established safety-related pharmacogenomics associations in six developed countries: an evaluation of alignment.The pharmacogenomics journal · 2017Article
- Epidemiology matters: peering inside the "black box" in economic evaluations of genetic testing.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Article
- Developing and evaluating polygenic risk prediction models for stratified disease prevention.Nature reviews. Genetics · 2016Review
- Was it worth it? Patients' perspectives on the perceived value of genomic-based individualized medicine.Journal of community genetics · 2016Article
- Association of PNPLA3 rs738409 and TM6SF2 rs58542926 with health services utilization in a population-based study.BMC health services research · 2016Article
- Capturing the clinical utility of genomic testing: medical recommendations following pediatric microarray.European journal of human genetics : EJHG · 2015Article
- Genomic analysis in the clinic: benefits and challenges for health care professionals and patients in Brazil.Journal of community genetics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research in genetics and genomics has led to an expanding list of molecular genetic tests, which are increasingly entering health care systems. However, the evidence surrounding the benefits and harms of these tests is frequently weak. Here we present the main challenges to the successful translation of new research findings about genotype-phenotype associations into clinical practice. We discuss the means to achieve an accelerated translation research agenda that is conducted in a reasonable, fair and efficient manner.
Indexed as
Identifiers
19506575What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.