Evidence map›Paper›PMID 19506565›Full record

SynthesisInternational journal of obesity (2005)2009

Is body mass index before middle age related to coronary heart disease risk in later life? Evidence from observational studies.

C G Owen, P H Whincup, L Orfei, Q-A Chou, A R Rudnicka, A K Wathern, S J Kaye, J G Eriksson, C Osmond, D G Cook

2 registry-linked trialsAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of obesity (2005), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 84 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00988754 nacompletednot on this map

School Children and Adolescents as Health Experts - Step 3

TypeinterventionalSponsorTechnical University of MunichRan2008 to 2012Enrolled595ConditionsObesity, Cardiovascular RiskArmsSchool children and adolescents as health experts
NCT01067157 nacompletednot on this map

Long-term Effects of Lifestyle Intervention in Obesity and Genetic Influence in Children - LOGIC-Study

TypeinterventionalSponsorTechnical University of MunichRan2006 to 2020Enrolled1,500ConditionsObesity, Cardiovascular RiskArmsLOGIC
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

C G OwenDivision of Community Health Sciences, St George's, University of London, London, UK.
P H Whincup
L Orfei
Q-A Chou
A R Rudnicka
A K Wathern
S J Kaye
J G Eriksson
C Osmond
D G Cook

Funding

British Heart Foundation PG/04/072
6 · The paper itself

Abstract

objectiveAlthough obesity beginning early in life is becoming more common, its implications for coronary heart disease (CHD) risk in later life remain uncertain. We examined the relationship of body mass index (BMI) before 30 years of age to CHD risk in later life.

designSystematic review of published studies relating BMI between age 2 and 30 years to later CHD risk. Studies were identified using Medline (1950 onwards), Embase (1980 onwards) and Web of Science (1970 onwards) databases (to November 2007). MEASUREMENTS: Relative risks (RR) of CHD associated with a 1 standard deviation (s.d.) higher BMI (most based on a narrow age range at measurement) were extracted by two authors independently, and combined using random-effect models.

resultsA total of 15 studies provided 17 estimates (731 337 participants, 23 894 CHD events) of the association of early BMI to later CHD outcome. BMI in early childhood (2-6 years, 3 estimates) showed a weak inverse association with CHD risk (RR 0.94, 95% CI 0.82-1.07). BMI in later childhood (7 to <18 years, 7 estimates) and BMI in early adult life (18-30 years, 7 estimates) were both positively related to later CHD risk (RR 1.09, 95% CI 1.00-1.20; RR 1.19, 95% CI 1.11-1.29 respectively). However, there was considerable statistical heterogeneity between study estimates. Results were unaffected by adjustment for social class and/or cigarette smoking, blood pressure and/or total cholesterol, in studies with available data. Gender and year of birth (1900-1976) had little effect on the association.

conclusionsBMI is positively related to CHD risk from childhood onwards; the associations in young adults are consistent with those observed in middle age. Long-term control of BMI from childhood may be important to reduce the risk of CHD.

Indexed as

Body Mass IndexAdolescentAdultAge FactorsChildChild, PreschoolCoronary DiseaseEvidence-Based MedicineFemaleHumansMaleObesityRisk FactorsSmokingUnited KingdomYoung Adult

Identifiers

PMID19506565
PMCPMC2726133

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.