ArticleNature2009
Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter.
Article in Nature, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 268 papers.
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Who cites it
268 citing papers in PubMed, 561 citations in OpenAlex.
- Brassinosteroid signaling regulates PIN5/10-mediated intracellular auxin homeostasis to promote lateral root development in tomato.Plant communications · 2026Article
- Metabolism meets transport: a new perspective on auxin homeostasis at subcellular level.Planta · 2026Review
- Expanding the triangle of U: comparative analysis of the Hirschfeldia incana genome provides insights into chromosomal evolution, phylogenomics and high photosynthesis-related traits.Annals of botany · 2026Article
- Pollen-expressed methionine synthases in Nicotiana tabacum regulate pollen development and germination.Plant physiology · 2026Article
- Sulfate starvation response modules connect sulfur metabolism to photorespiration and photosynthesis.The Plant journal : for cell and molecular biology · 2026Article
- Genome-wide identification and expression pattern analysis under drought stress of PHD family genes in alfalfa (Medicago sativa).BMC genomics · 2025Article
- The evolution and developmental expression profile of the PIN-FORMED family in Setaria viridis.Plant molecular biology · 2025Article
- ERAD machinery controls the conditional turnover of PIN-LIKES in plants.Science advances · 2025Article
- Mechanisms of auxin action in plant growth and development.Nature reviews. Molecular cell biology · 2025Review
- Regulatory Mechanism of the GmMYB14 Transcription Factor on Auxin-Related Proteins in Soybean.International journal of molecular sciences · 2025Article
- An Investigation into the Evolutionary Characteristics and Expression Patterns of the Basic Leucine Zipper Gene Family in the Endangered SpeciesPlants (Basel, Switzerland) · 2025Article
- Knockout ofPlants (Basel, Switzerland) · 2025Article
- The Crucial Roles of Phloem Companion Cells in Response to Phosphorus Deficiency.Plant, cell & environment · 2025Article
- ThePlants (Basel, Switzerland) · 2025Article
- The role of indole-3-acetic acid and characterization of PIN transporters in complex streptophyte alga Chara braunii.The New phytologist · 2025Article
- Plasmopara viticola Effector PvRXLR10 Targets a Host Phospholipase VvipPLA-IIδ2 to Suppress Plant Immunity in Grapevine.Molecular plant pathology · 2025Article
- PIN2-mediated self-organizing transient auxin flow contributes to auxin maxima at the tip of Arabidopsis cotyledons.Nature communications · 2025Article
- Antioxidants by nature: an ancient feature at the heart of flavonoids' multifunctionality.The New phytologist · 2025Article
- The SlERF4-9-SlCDF1/3-SlAEC2/SlPIN5 module regulates tomato root morphogenesis.Frontiers in plant science · 2025Article
- Transcriptomic and hormonal dynamics in relation to adventitious rooting of two parentalFrontiers in plant science · 2025Article
208 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 8 institutions in 5 countries.
Funding
Abstract
The plant signalling molecule auxin provides positional information in a variety of developmental processes by means of its differential distribution (gradients) within plant tissues. Thus, cellular auxin levels often determine the developmental output of auxin signalling. Conceptually, transmembrane transport and metabolic processes regulate the steady-state levels of auxin in any given cell. In particular, PIN auxin-efflux-carrier-mediated, directional transport between cells is crucial for generating auxin gradients. Here we show that Arabidopsis thaliana PIN5, an atypical member of the PIN gene family, encodes a functional auxin transporter that is required for auxin-mediated development. PIN5 does not have a direct role in cell-to-cell transport but regulates intracellular auxin homeostasis and metabolism. PIN5 localizes, unlike other characterized plasma membrane PIN proteins, to endoplasmic reticulum (ER), presumably mediating auxin flow from the cytosol to the lumen of the ER. The ER localization of other PIN5-like transporters (including the moss PIN) indicates that the diversification of PIN protein functions in mediating auxin homeostasis at the ER, and cell-to-cell auxin transport at the plasma membrane, represent an ancient event during the evolution of land plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.