ArticleJournal of burn care & research : official publication of the American Burn Association
Sustained impairments in cutaneous vasodilation and sweating in grafted skin following long-term recovery.
Article in Journal of burn care & research : official publication of the American Burn Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Exercise and Heat Stress in Well-Healed Burn Survivors: Effects of Cooling Modalities on Thermal and Perceptual Responses.Medicine and science in sports and exercise · 2025Trial
- Interaction of Exercise Intensity and Simulated Burn Injury Size on Thermoregulation.Medicine and science in sports and exercise · 2021Trial
- Does attenuated skin blood flow lower sweat rate and the critical environmental limit for heat balance during severe heat exposure?Experimental physiology · 2017Trial
- Aerobic training improves in vivo cholinergic responsiveness but not sensitivity of eccrine sweat glands.The Journal of investigative dermatology · 2010Trial
- Effect of burn injury size on cardiovascular responses to exercise in the heat.European journal of applied physiology · 2025Article
- Burn size and environmental conditions modify thermoregulatory responses to exercise in burn survivors.Journal of burn care & research : official publication of the American Burn Association · 2024Article
- Inhibiting regional sweat evaporation modifies the ventilatory response to exercise: interactions between core and skin temperature.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Human temperature regulation under heat stress in health, disease, and injury.Physiological reviews · 2022Review
- Edward F. Adolph Distinguished Lecture. It's more than skin deep: thermoregulatory and cardiovascular consequences of severe burn injuries in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Temperature Sensitivity After Burn Injury: A Burn Model System National Database Hot Topic.Journal of burn care & research : official publication of the American Burn Association · 2021Article
- Burn Injury Does Not Exacerbate Heat Strain during Exercise while Wearing Body Armor.Medicine and science in sports and exercise · 2020Article
- Exercise Core Temperature Response with a Simulated Burn Injury: Effect of Body Size.Medicine and science in sports and exercise · 2020Article
- Exercise Thermoregulation with a Simulated Burn Injury: Impact of Air Temperature.Medicine and science in sports and exercise · 2020Article
- No Thermoregulatory Impairment in Skin Graft Donor Sites during Exercise-Heat Stress.Medicine and science in sports and exercise · 2019Article
- Physiology of sweat gland function: The roles of sweating and sweat composition in human health.Temperature (Austin, Tex.) · 2019Review
- Vasodilator function is impaired in burn injury survivors.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Frey's syndrome following a facial burn treated with botulinum toxin.Annals of burns and fire disasters · 2018Article
- Current concepts of active vasodilation in human skin.Temperature (Austin, Tex.) · 2017Review
- Heat acclimation improves heat exercise tolerance and heat dissipation in individuals with extensive skin grafts.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Decreased skin-mediated detoxification contributes to oxidative stress and insulin resistance.Experimental diabetes research · 2012Article
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Authors and funding
11 authors.
Funding
Abstract
We previously identified impaired cutaneous vasodilation and sweating in grafted skin 5 to 9 months postsurgery. The aim of this investigation was to test the hypothesis that cutaneous vasodilation, but not sweating, is restored as the graft heals. Skin blood flow and sweat rate were assessed from grafted skin and adjacent noninjured skin in three groups of subjects: 5 to 9 months postsurgery (n=13), 2 to 3 years postsurgery (n=13), and 4 to 8 years postsurgery (n=13) during three separate protocols: 1) whole-body heating and cooling, 2) local administration of vasoactive drugs, and 3) local heating and cooling. Cutaneous vasodilation and sweating during whole-body heating were significantly lower (P<.001) in grafted skin when compared with noninjured skin across all groups and demonstrated no improvements with recovery time postsurgery. Maximal endothelial-dependent (acetylcholine) and endothelial-independent (sodium nitroprusside) cutaneous vasodilation remained attenuated (P<.001) in grafted skin up to 4 to 8 years postsurgery, indicating postsynaptic impairments. In grafted skin, cutaneous vasoconstriction during whole-body and local cooling was preserved, whereas vasodilation to local heating was impaired, regardless of the duration postsurgery. Split-thickness skin grafts have impaired cutaneous vasodilation and sweating up to 4 to 8 years postsurgery, thereby limiting the capability of this skin's contribution to thermoregulation during a heats stress. In contrast, grafted skin has preserved vasoconstrictor capacity.
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