ArticleJournal of acquired immune deficiency syndromes (1999)2009
Detection of individuals with acute HIV-1 infection using the ARCHITECT HIV Ag/Ab Combo assay.
Article in Journal of acquired immune deficiency syndromes (1999), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The trial behind it
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Use of a multifaceted approach to analyze HIV incidence in a cohort study of women in the United States: HIV Prevention Trials Network 064 Study.The Journal of infectious diseases · 2013Trial
- HIV surveillance in a large, community-based study: results from the pilot study of Project Accept (HIV Prevention Trials Network 043).BMC infectious diseases · 2011Trial
- Different approaches to HIV confirmation: a survey of three Italian regions.Frontiers in cellular and infection microbiology · 2026Article
- Evaluation of a point-of-care rapid HIV antibody test with insights into acute HIV symptomatology in a population with low prevalence.Journal of clinical microbiology · 2024Article
- Utility of the Signal-to-Cutoff Ratio and Antigen Index from Fourth- and Fifth-Generation HIV-1/HIV-2 Antigen/Antibody Assays for the Diagnosis of Acute HIV Infection: Applicability for Real-Time Use for Immediate Initiation of Antiretroviral Therapy.Journal of clinical microbiology · 2022Article
- Evaluation of the Abbott ARCHITECT HIV Ag/Ab combo assay for determining recent HIV-1 infection.PloS one · 2021Article
- Costs per Diagnosis of Acute HIV Infection in Community-based Screening Strategies: A Comparative Analysis of Four Screening Algorithms.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- HIV testing updates and challenges: when regulatory caution and public health imperatives collide.Current HIV/AIDS reports · 2015Article
- Individualized diagnosis interventions can add significant effectiveness in reducing human immunodeficiency virus incidence among men who have sex with men: insights from Southern California.Annals of epidemiology · 2015Article
- Prolonged second diagnostic window for human immunodeficiency virus type 1 in a fourth-generation immunoassay: are alternative testing strategies required?Journal of clinical microbiology · 2014Article
- Poor performance of the determine HIV-1/2 Ag/Ab combo fourth-generation rapid test for detection of acute infections in a National Household Survey in Swaziland.Journal of clinical microbiology · 2014Article
- Prevalence of undiagnosed acute and chronic HIV in a lower-prevalence urban emergency department.American journal of public health · 2014Article
- Generation of a recombinant Gag virus-like-particle panel for the evaluation of p24 antigen detection by diagnostic HIV tests.PloS one · 2014Article
- Evaluation of the CDC proposed laboratory HIV testing algorithm among men who have sex with men (MSM) from five US metropolitan statistical areas using specimens collected in 2011.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2013Article
- The detection and management of early HIV infection: a clinical and public health emergency.Journal of acquired immune deficiency syndromes (1999) · 2013Review
- Performance of rapid point-of-care and laboratory tests for acute and established HIV infection in San Francisco.PloS one · 2013Article
- HIV transmission.Cold Spring Harbor perspectives in medicine · 2012Review
- Cost savings associated with testing of antibodies, antigens, and nucleic acids for diagnosis of acute HIV infection.Journal of clinical microbiology · 2012Article
- Should we treat acute HIV infection?Current HIV/AIDS reports · 2012Review
- Detection of acute HIV infection: a field evaluation of the determine® HIV-1/2 Ag/Ab combo test.The Journal of infectious diseases · 2012Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundWe evaluated use of the ARCHITECT HIV Ag/Ab Combo assay (HIV Combo; Abbott Diagnostics; available for sale outside the United States only) for detection of acute HIV infection.
methodsSamples were obtained from a behavioral intervention study (EXPLORE). HIV-uninfected men who have sex with men were enrolled and tested for HIV infection every 6 months. Samples from seroconverters collected at their last seronegative visit (n = 217) were tested individually using 2 HIV RNA assays. Samples with detectable HIV RNA were classified as acute and were tested with HIV Combo. Samples from the enrollment visit (n = 83) and the time of HIV seroconversion (n = 219) were tested with HIV Combo as controls.
resultsTwenty-one samples (9.7%) from the last seronegative visit had detectable HIV RNA and were classified as acute. HIV Combo was positive for 13 of the acute samples (61.9%). Samples not detected by HIV Combo had viral loads of 724-15,130 copies per milliliter. Expected results were obtained for positive and negative controls tested with HIV Combo.
conclusionsHIV Combo detected nearly two thirds of acute HIV infections identified in this high-risk population by non-pooled HIV RNA assays. HIV Combo may be useful for high-throughput screening to identify individuals with acute HIV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.