ReviewILAR journal2009
Metabolic consequences of sleep-disordered breathing.
Review in ILAR journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 102 citations in OpenAlex.
- Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol During Sleep.The Journal of clinical endocrinology and metabolism · 2017Trial
- Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans.Metabolism: clinical and experimental · 2010Trial
- Outcome of Targeted Therapy for Obstructive Sleep Apnea in Children with Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).Children (Basel, Switzerland) · 2026Article
- Role for endothelin-1 in cardiometabolic dysfunction with intermittent hypoxia.Function (Oxford, England) · 2026Review
- The association of the non-HDL-cholesterol to HDL-cholesterol ratio (NHHR) with obstructive sleep apnea among adults aged ≥ 40 years: results from NHANES 2015-2018.BMC public health · 2025Article
- Upregulation of IL-8, osteonectin, and myonectin mRNAs by intermittent hypoxia via OCT1- and NRF2-mediated mechanisms in skeletal muscle cells.Journal of cellular and molecular medicine · 2022Article
- Endothelin-1 as a novel target for the prevention of metabolic dysfunction with intermittent hypoxia in male participants.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Sleep Apnea and Cardiovascular Disease.Current diabetes reports · 2021Review
- Role of obstructive sleep apnea in metabolic risk in PCOS.Current opinion in endocrine and metabolic research · 2021Article
- Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets.International journal of molecular sciences · 2020Review
- Article
- Review
- The Relationship Between Obstructive Sleep Apnea and Coronary Plaque: A Coronary Computed Tomographic Angiography Study.Acta Cardiologica Sinica · 2019Article
- Neural Circuitry Underlying Waking Up to Hypercapnia.Frontiers in neuroscience · 2019Review
- Murine models of sleep apnea: functional implications of altered macrophage polarity and epigenetic modifications in adipose and vascular tissues.Metabolism: clinical and experimental · 2018Review
- Life Under Hypoxia Lowers Blood Glucose Independently of Effects on Appetite and Body Weight in Mice.Frontiers in endocrinology · 2018Article
- Accurate discrimination of the wake-sleep states of mice using non-invasive whole-body plethysmography.Scientific reports · 2017Article
- Stressful sleep.The European respiratory journal · 2016Article
- Airway cell involvement in intermittent hypoxia-induced airway inflammation.Sleep & breathing = Schlaf & Atmung · 2015Article
- Inflammation in sleep apnea: an update.Reviews in endocrine & metabolic disorders · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
There is increasing evidence of a causal relationship between sleep-disordered breathing and metabolic dysfunction. Metabolic syndrome (MetS), a cluster of risk factors that promote atherosclerotic cardiovascular disease, comprises central obesity, insulin resistance, glucose intolerance, dyslipidemia, and hypertension, manifestations of altered total body energy regulation. Excess caloric intake is indisputably the key driver of MetS, but other environmental and genetic factors likely play a role; in particular, obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), may induce or exacerbate various aspects of MetS. Clinical studies show that OSA can affect glucose metabolism, cholesterol, inflammatory markers, and nonalcoholic fatty liver disease. Animal models of OSA enable scientists to circumvent confounders such as obesity in clinical studies. In the most widely used model, which involves exposing rodents to IH during their sleep phase, the IH alters circadian glucose homeostasis, impairs muscle carbohydrate uptake, induces hyperlipidemia, and upregulates cholesterol synthesis enzymes. Complicating factors such as obesity or a high-fat diet lead to progressive insulin resistance and liver inflammation, respectively. Mechanisms for these effects are not yet fully understood, but are likely related to energy-conserving adaptations to hypoxia, which is a strong catabolic stressor. Finally, IH may contribute to the morbidity of MetS by inducing inflammation and oxidative stress. Identification of OSA as a potential causative factor in MetS would have immense clinical impact and could improve the management and understanding of both disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.