Evidence map›Paper›PMID 19506115›Full record

ArticleCirculation2009

Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute.

Douglas S Lee, Philimon Gona, Ramachandran S Vasan, Martin G Larson, Emelia J Benjamin, Thomas J Wang, Jack V Tu, Daniel Levy

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04190420 (The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study), which is not on this map. Cited by 279 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
279citing papers in PubMed, 6 pooled it
23.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04190420 unknown statusnot on this mapstarted 2018, after this paper: background citation

The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study

TypeobservationalSponsorKarolinska InstitutetRan2018 to 2025Enrolled310ConditionsHypertension, Heart Failure, Hypertensive Heart Disease, Diastolic Dysfunction
3 · Its place in the literature

Who cites it

279 citing papers in PubMed, 6 syntheses or guidelines pooled it, 674 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Electrocardiographic characteristics in patients with heart failure and normal ejection fraction: A systematic review and meta-analysis.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2020
    Pooled it
  4. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019
    Guideline
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Changes in left ventricular filling parameters following catheter ablation of atrial fibrillation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2016
    Trial
  14. Trial
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

219 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Douglas S LeeDirector, Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702-5827, USA.
Philimon Gona
Ramachandran S Vasan
Martin G Larson
Emelia J Benjamin
Thomas J Wang
Jack V Tu
Daniel Levy
Boston University · USHarvard University · USHealth Sciences Centre · CASunnybrook Health Science Centre · CAUniversity of Toronto · CA

Funding

Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Framingham Project/LevyZ01HL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2008 to 2008
$1.1M
ASYMPTOMATIC LEFT VENTRICULAR DYSFUNCTIONK24HL004334 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2001 to 2008
$707k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
Intramural NIH HHS Z01 HL006001Intramural NIH HHS Z99 HL999999NHLBI NIH HHS K24 HL004334NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01-HL-25195
6 · The paper itself

Abstract

backgroundThe contributions of risk factors and disease pathogenesis to heart failure with preserved ejection fraction (HFPEF) versus heart failure with reduced ejection fraction (HFREF) have not been fully explored. METHODS AND

resultsWe examined clinical characteristics and risk factors at time of heart failure onset and long-term survival in Framingham Heart Study participants according to left ventricular ejection fraction < or =45% (n=314; 59%) versus >45% (n=220; 41%) and hierarchical causal classification. Heart failure was attributed to coronary heart disease in 278 participants (52%), valvular heart disease in 42 (8%), hypertension in 140 (26%), or other/unknown causes in 74 (14%). Multivariable predictors of HFPEF (versus HFREF) included elevated systolic blood pressure (odds ratio [OR]=1.13 per 10 mm Hg; 95% confidence interval [CI], 1.04 to 1.22), atrial fibrillation (OR=4.23; 95% CI, 2.38 to 7.52), and female sex (OR=2.29; 95% CI, 1.35 to 3.90). Conversely, prior myocardial infarction (OR=0.32; 95% CI, 0.19 to 0.53) and left bundle-branch block QRS morphology (OR=0.21; 95% CI, 0.10 to 0.46) reduced the odds of HFPEF. Long-term prognosis was grim, with a median survival of 2.1 years (5-year mortality rate, 74%), and was equally poor in men and women with HFREF or HFPEF.

conclusionsAmong community patients with new-onset heart failure, there are differences in causes and time-of-onset clinical characteristics between those with HFPEF versus HFREF. In people with HFREF, mortality is increased when coronary heart disease is the underlying cause. These findings suggest that heart failure with reduced left ventricular systolic function and heart failure with preserved left ventricular systolic function are partially distinct entities, with potentially different approaches to early detection and prevention.

Indexed as

Blood PressureHeart FailureStroke VolumeVentricular Function, LeftAgedAged, 80 and overAge of OnsetCohort StudiesFemaleHumansMaleMassachusettsMiddle AgedNational Heart, Lung, and Blood Institute (U.S.)PrognosisRisk Factors

Identifiers

PMID19506115
PMCPMC2775498
OpenAlexW2144048294

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.