ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2009
Cell death-associated ADAMTS4 and versican degradation in vascular tissue.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- ADAMTS4 elicits myeloid-derived immune cell recruitment and liver fibrogenesis in metabolic dysfunction-associated steatotic liver disease.Signal transduction and targeted therapy · 2026Article
- Early Injury Landscape in Vein Harvest by Single-Cell and Spatial Transcriptomics.Circulation research · 2024Article
- Integrated single-nuclei and spatial transcriptomic analysis reveals propagation of early acute vein harvest and distension injury signaling pathways following arterial implantation.bioRxiv : the preprint server for biology · 2024Article
- Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction.Cardiovascular research · 2023Article
- Article
- Transcriptome profiling revealed early vascular smooth muscle cell gene activation following focal ischemic stroke in female rats - comparisons with males.BMC genomics · 2020Article
- ADAMTS proteases in cardiovascular physiology and disease.Open biology · 2020Review
- Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm.American journal of physiology. Heart and circulatory physiology · 2020Review
- A role for proteoglycans in vascular disease.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.Scientific reports · 2017Article
- Interplay of extracellular matrix and leukocytes in lung inflammation.Cellular immunology · 2017Review
- Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice.Scientific reports · 2016Article
- Regulation of hyaluronan synthesis in vascular diseases and diabetes.Journal of diabetes research · 2015Review
- Versican and the regulation of cell phenotype in disease.Biochimica et biophysica acta · 2014Review
- Homotypic versican G1 domain interactions enhance hyaluronan incorporation into fibrillin microfibrils.The Journal of biological chemistry · 2013Article
- ADAMTS-1 and ADAMTS-4 levels are elevated in thoracic aortic aneurysms and dissections.The Annals of thoracic surgery · 2013Article
- Increased expression of ADAMTS13 mRNA correlates with ischemic cerebrovascular disease in systemic lupus erythematosus patients.SAGE open medicine · 2013Article
- Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.Developmental biology · 2011Article
- A link between smooth muscle cell death and extracellular matrix degradation during vascular atrophy.Journal of vascular surgery · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
High blood flow through baboon polytetrafluorethylene aorto-iliac grafts increases neointimal vascular smooth muscle cell (SMC) death, neointimal atrophy, and cleavage of versican to generate the DPEAAE neoepitope, a marker of ADAMTS-mediated proteolysis. In this study, we have determined the effect of high blood flow on transcript abundance in the neointima for ADAMTS1, -4, -5, -8, -9, -15, and -20. We found that after 24 hr of flow, the mRNA for ADAMTS4 was significantly increased, whereas that for the other family members was unchanged. Because vascular SMC death is markedly increased in the graft after 24 hr of high flow, we next examined the possibility that the ADAMTS4 induction and the cell death are causally related. The addition of Fas ligand to SMC cultures increased both ADAMTS4 mRNA and cell death approximately 5-fold, consistent with the idea that ADAMTS4-dependent cleavage of versican may be partly responsible for cell death and tissue atrophy under these conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.