ArticleInfection and immunity2009
Comparative analysis of the locus of enterocyte effacement and its flanking regions.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Characterisation of Typical Enteropathogenic Escherichia coli (tEPEC) and bfpA Genes From Five Bat Species Reveals Australian Pteropus Spp. Are Natural tEPEC Hosts.MicrobiologyOpen · 2026Article
- Comparative genomic analyses ofmSystems · 2026Article
- Genome on the move: emergence of hybrid atypical enteropathogenic/enteroaggregativeMicrobiology spectrum · 2026Article
- Novel strains of typical enteropathogenicMicrobial genomics · 2025Article
- Polyphosphate Kinase 1 Is a Pathogenesis Determinant in EnterohemorrhagicFrontiers in microbiology · 2021Article
- Is Shiga Toxin-ProducingMicroorganisms · 2020Article
- Pathogenicity Factors of Genomic Islands in Intestinal and ExtraintestinalFrontiers in microbiology · 2020Review
- Enterobacteria and host resistance to infection.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Diarrheagenic Escherichia coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2016Review
- Evolution of atypical enteropathogenic E. coli by repeated acquisition of LEE pathogenicity island variants.Nature microbiology · 2016Article
- High Iron-Sequestrating Bifidobacteria Inhibit Enteropathogen Growth and Adhesion to Intestinal Epithelial CellsFrontiers in microbiology · 2016Article
- Comprehensive Characterization of Escherichia coli O104:H4 Isolated from Patients in the Netherlands.Frontiers in microbiology · 2015Article
- Genetic evaluation of Locus of enterocyte effacement pathogenicity island (LEE) in Enteropathogenic Escherichia coli isolates (EPEC).Iranian journal of microbiology · 2013Article
- Virulence gene profiles and population genetic analysis for exploration of pathogenic serogroups of Shiga toxin-producing Escherichia coli.Journal of clinical microbiology · 2013Article
- Recent advances in understanding enteric pathogenic Escherichia coli.Clinical microbiology reviews · 2013Review
- Use of antibody responses against locus of enterocyte effacement (LEE)-encoded antigens to monitor enterohemorrhagic Escherichia coli infections on cattle farms.Applied and environmental microbiology · 2013Article
- Phylogenetic and molecular analysis of food-borne shiga toxin-producing Escherichia coli.Applied and environmental microbiology · 2013Article
- Genetic diversity of locus of enterocyte effacement genes of enteropathogenic Escherichia coli isolated from Peruvian children.Journal of medical microbiology · 2012Article
- Article
- Enterohemorrhagic E. coli (EHEC) pathogenesis.Frontiers in cellular and infection microbiology · 2012Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The attaching-and-effacing (A/E) phenotype mediated by factors derived from the locus of enterocyte effacement (LEE) is a hallmark of clinically important intestinal pathotypes of Escherichia coli, including enteropathogenic (EPEC), atypical EPEC (ATEC), and enterohemorrhagic E. coli strains. Epidemiological studies indicate that the frequency of diarrhea outbreaks caused by ATEC is increasing. Hence, it is of major importance to further characterize putative factors contributing to the pathogenicity of these strains and to gain additional insight into the plasticity and evolutionary aspects of this emerging pathotype. Here, we analyzed the two clinical ATEC isolates B6 (O26:K60) and 9812 (O128:H2) and compared the genetic organizations, flanking regions, and chromosomal insertion loci of their LEE with those of the LEE of other A/E pathogens. Our analysis shows that the core LEE is largely conserved-particularly among genes coding for the type 3 secretion system-whereas genes encoding effector proteins display a higher variability. Chromosomal insertion loci appear to be restricted to selC, pheU, and pheV. In contrast, striking differences were found between the 5'- and 3'-associated flanking regions reflecting the different histories of the various strains and also possibly indicating different lines in evolution.
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