ArticleInfection and immunity2009
Host adhesive activities and virulence of novel fimbrial proteins of Porphyromonas gingivalis.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Transcriptional modulation of Porphyromonas gingivalis biofilms on titanium-copper implant surfaces.Folia microbiologica · 2025Article
- Alzheimer's Disease andLife (Basel, Switzerland) · 2025Review
- Architectural dissection of adhesive bacterial cell surface appendages from a "molecular machines" viewpoint.Journal of bacteriology · 2024Review
- The potential crosstalk genes and molecular mechanisms between glioblastoma and periodontitis.Scientific reports · 2024Article
- TLR2 Activation byFrontiers in immunology · 2022Article
- Article
- Roles of Porphyromonas gingivalis and its virulence factors in periodontitis.Advances in protein chemistry and structural biology · 2020Review
- Maturation of the Mfa1 Fimbriae in the Oral PathogenFrontiers in cellular and infection microbiology · 2018Article
- Article
- Genes Contributing toFrontiers in cellular and infection microbiology · 2017Article
- Sex dimorphism in periodontitis in animal models.Journal of periodontal research · 2016Article
- Genetic exchange of fimbrial alleles exemplifies the adaptive virulence strategy of Porphyromonas gingivalis.PloS one · 2014Article
- Mechanism and implications of CXCR4-mediated integrin activation by Porphyromonas gingivalis.Molecular oral microbiology · 2013Article
- Genetic diversity in the oral pathogen Porphyromonas gingivalis: molecular mechanisms and biological consequences.Future microbiology · 2013Review
- Inhibition of Porphyromonas gingivalis-induced periodontal bone loss by CXCR4 antagonist treatment.Molecular oral microbiology · 2012Article
- Article
- Manipulation of kinase signaling by bacterial pathogens.The Journal of cell biology · 2011Review
- Stick to your gums: mechanisms of oral microbial adherence.Journal of dental research · 2011Review
- Microbial manipulation of receptor crosstalk in innate immunity.Nature reviews. Immunology · 2011Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
The fimbriae of Porphyromonas gingivalis mediate critical roles in host colonization and evasion of innate defenses and comprise polymerized fimbrilin (FimA) associated with quantitatively minor accessory proteins (FimCDE) of unknown function. We now show that P. gingivalis fimbriae lacking FimCDE fail to interact with the CXC-chemokine receptor 4 (CXCR4), and bacteria expressing FimCDE-deficient fimbriae cannot exploit CXCR4 in vivo for promoting their persistence, as the wild-type organism does. Consistent with these loss-of-function experiments, purified FimC and FimD (but not FimE) were shown to interact with CXCR4. However, significantly stronger binding was observed when a combination of all three proteins was allowed to interact with CXCR4. In addition, FimC and FimD bound to fibronectin and type 1 collagen, whereas FimE failed to interact with these matrix proteins. These data and the fact that FimE is required for the association of FimCDE with P. gingivalis fimbriae suggest that FimE may recruit FimC and FimD into a functional complex, rather than directly binding host proteins. Consistent with this notion, FimE was shown to bind both FimC and FimD. In summary, the FimCDE components cooperate and impart critical adhesive and virulence properties to P. gingivalis fimbriae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.