ArticleMolecular human reproduction2009
Induction of endometrial epithelial cell invasion and c-fms expression by transforming growth factor beta.
Article in Molecular human reproduction, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Immune mechanisms in the pathogenesis of endometriosis: a comprehensive analysis of the role of NK cells, cytokines, and extracellular vesicles/exosomes.Frontiers in immunology · 2026Review
- Hypersensitive intercellular responses of endometrial stromal cells drive invasion in endometriosis.eLife · 2024Article
- Inhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis.Endocrinology · 2024Article
- COVID-19 susceptibility in endometriosis patients: A case control study.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022Article
- Macrophages Protect Endometriotic Cells Against Oxidative Damage Through a Cross-Talk Mechanism.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Cellular junction and mesenchymal factors delineate an endometriosis-specific response of endometrial stromal cells to the mesothelium.Molecular and cellular endocrinology · 2022Article
- Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†.Biology of reproduction · 2021Review
- Efficacy of niclosamide on the intra-abdominal inflammatory environment in endometriosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Growth inhibitory efficacy and anti-aromatase activity ofBiomedical reports · 2019Article
- Knockdown of vascular cell adhesion molecule 1 impedes transforming growth factor beta 1-mediated proliferation, migration, and invasion of endometriotic cyst stromal cells.Reproductive biology and endocrinology : RB&E · 2019Article
- Anti-inflammatory cytokines in endometriosis.Cellular and molecular life sciences : CMLS · 2019Review
- Perineural invasion in endometriotic lesions contributes to endometriosis-associated pain.Journal of pain research · 2018Article
- An efficient model of human endometriosis by induced unopposed estrogenicity in baboons.Oncotarget · 2016Article
- Effects of a novel proteasome inhibitor BU-32 on multiple myeloma cells.Cancer chemotherapy and pharmacology · 2014Article
- BMPR1B up-regulation via a miRNA binding site variation defines endometriosis susceptibility and CA125 levels.PloS one · 2013Article
- Pathogenesis and pathophysiology of endometriosis.Fertility and sterility · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Transforming growth factor beta 1 (TGF-beta1) levels are increased in the peritoneal fluid of endometriosis patients, and endometrial cells express TGF-beta signaling components; however, little is known regarding the role of TGF-beta in endometriosis. Our objective was to examine the effects of TGF-beta1 on (i) the expression of macrophage colony-stimulating factor receptor encoded by the c-fms gene, (ii) transmesothelial invasiveness of endometrial cells, (iii) cellular proliferation and (iv) attachment to peritoneal mesothelial cells (PMCs). Effects of TGF-beta1 on c-fms mRNA expression were determined by real-time RT-PCR and c-fms cell-surface expression by flow cytometry. Effects of TGF-beta1 on the invasiveness of the immortalized endometrial epithelial cell (EEC) line EM42 and primary EECs were examined using a three-dimensional in vitro system modeling the peritoneum. Cellular proliferation and attachment to PMCs were also examined using established techniques. TGF-beta1 had little or no effect on cellular proliferation and endometrial cell attachment to PMCs. TGF-beta1 significantly induced the expression of c-fms mRNA and c-fms cell-surface expression. TGF-beta1 enhanced transmesothelial invasion by EM42 cells and EECs. Antagonists of TGF-beta1 signaling significantly inhibited both the induction of c-fms expression and cellular invasiveness, suggesting that additional studies are warranted to assess the therapeutic potential of TGF-beta antagonists in endometriosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.