ArticleThe Journal of physiology2009
Peripheral sensitisation of nociceptors via G-protein-dependent potentiation of mechanotransduction currents.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 63 citations in OpenAlex.
- Derivation and analysis of human somatic sensory neuron subtypes facilitated through fluorescent hPSC reporters.Stem cell reports · 2026Article
- The activation thresholds and inactivation kinetics of poking-evoked PIEZO1 and PIEZO2 currents are sensitive to subtle variations in mechanical stimulation parameters.Channels (Austin, Tex.) · 2024Article
- Localization of Piezo 1 and Piezo 2 in Lateral Line System and Inner Ear of Zebrafish (International journal of molecular sciences · 2024Article
- Piezo 1 and Piezo 2 in the Chemosensory Organs of Zebrafish (International journal of molecular sciences · 2024Article
- Role of TMEM100 in mechanically insensitive nociceptor un-silencing.Nature communications · 2023Article
- Lack of evidence for participation of TMEM150C in sensory mechanotransduction.The Journal of general physiology · 2022Article
- Peripheral mechanisms of chronic pain.Medical review (2021) · 2022Review
- Patch-seq of mouse DRG neurons reveals candidate genes for specific mechanosensory functions.Cell reports · 2021Article
- The Form and Function of PIEZO2.Annual review of biochemistry · 2021Review
- Structure-guided examination of the mechanogating mechanism of PIEZO2.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Nociceptor Signalling through ion Channel Regulation via GPCRs.International journal of molecular sciences · 2019Review
- Voltage gating of mechanosensitive PIEZO channels.Nature communications · 2018Article
- Article
- Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.Nature neuroscience · 2017Article
- Regulation of Piezo Channels by Cellular Signaling Pathways.Current topics in membranes · 2017Review
- Phosphoinositide signaling in somatosensory neurons.Advances in biological regulation · 2016Review
- Enhancement of acid-sensing ion channel activity by metabotropic P2Y UTP receptors in primary sensory neurons.Purinergic signalling · 2016Article
- P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Sensory mechanotransduction at membrane-matrix interfaces.Pflugers Archiv : European journal of physiology · 2015Review
- G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels.Pflugers Archiv : European journal of physiology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanical stimuli impinging on the skin are converted into electrical signals by mechanically gated ion channels located at the peripheral nerve endings of dorsal root ganglion (DRG) neurons. Under inflammatory conditions sensory neurons are commonly sensitised to mechanical stimuli; a putative mechanism that may contribute to such sensitisation of sensory neurons is enhanced responsiveness of mechanotransduction ion channels. Here we show that the algogens UTP and ATP potentiate mechanosensitive RA currents in peptidergic nociceptive DRG neurons and reduce thresholds for mechanically induced action potential firing in these neurones. Pharmacological characterisation suggests that this effect is mediated by the Gq-coupled P2Y(2) nucleotide receptor. Moreover, using the in vitro skin nerve technique, we show that UTP also increases action potential firing rates in response to mechanical stimuli in a subpopulation of skin C-fibre nociceptors. Together our findings suggest that UTP sensitises a subpopulation of cutaneous C-fibre nociceptors via a previously undescribed G-protein-dependent potentiation of mechanically activated RA-type currents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.