ArticleEvidence-based complementary and alternative medicine : eCAM2011
Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Trial
- Preventive and inhibitory effects ofBiochemistry and biophysics reports · 2026Article
- Article
- Herbal tea, a novel adjuvant therapy for treating type 2 diabetes mellitus: A review.Frontiers in pharmacology · 2022Review
- Obesity-Linked Cancers: Current Knowledge, Challenges and Limitations in Mechanistic Studies and Rodent Models.Cancers · 2018Review
- Tsumura-Suzuki obese diabetic mice-derived hepatic tumors closely resemble human hepatocellular carcinomas in metabolism-related genes expression and bile acid accumulation.Hepatology international · 2018Article
- Anti-diabetic and Anti-hyperlipidemic Effects and Safety of Salacia reticulata and Related Species.Phytotherapy research : PTR · 2015Review
- Salacia reticulata (Kothala himbutu) revisited; a missed opportunity to treat diabetes and obesity?Nutrition journal · 2015Review
- Type 2 diabetes model TSOD mouse is exposed to oxidative stress at young age.Journal of clinical biochemistry and nutrition · 2014Article
- Salacia reticulata has therapeutic effects on obesity.Journal of natural medicines · 2014Article
- Sorghum extract exerts an anti-diabetic effect by improving insulin sensitivity via PPAR-γ in mice fed a high-fat diet.Nutrition research and practice · 2012Article
- Preventive effect of Terminalia bellirica on obesity and metabolic disorders in spontaneously obese type 2 diabetic model mice.Journal of natural medicines · 2012Article
- A mixture of Salacia oblonga extract and IP-PA1 reduces fasting plasma glucose (FPG) and low-density lipoprotein (LDL) cholesterol levels.Nutrition research and practice · 2011Article
- Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice.Journal of natural medicines · 2011Article
- Anti-Obesity and Anti-Diabetic Effects of Acacia Polyphenol in Obese Diabetic KKAy Mice Fed High-Fat Diet.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Preventive effect of pine bark extract (flavangenol) on metabolic disease in Western diet-loaded tsumura suzuki obese diabetes mice.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata.Journal of natural medicines · 2010Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extracts of Salacia reticulata (Salacia extract), a plant that has been used for the treatment of early diabetes, rheumatism and gonorrhea in Ayurveda, have been shown to have an anti-obesity effect and suppress hyperglycemia. In this study, the effects of Salacia extract on various symptoms of metabolic disorder were investigated and compared using these TSOD mice and non-obese TSNO mice. Body weight, food intake, plasma biochemistry, visceral and subcutaneous fat (X-ray and CT), glucose tolerance, blood pressure and pain tolerance were measured, and histopathological examination of the liver was carried out. A significant dose-dependent decline in the gain in body weight, accumulation of visceral and subcutaneous fat and an improvement of abnormal glucose tolerance, hypertension and peripheral neuropathy were noticed in TSOD mice. In addition, hepatocellular swelling, fatty degeneration of hepatocytes, inflammatory cell infiltration and single-cell necrosis were observed on histopathological examination of the liver in TSOD mice. Salacia extract markedly improved these symptoms upon treatment. Based on the above results, it is concluded that Salacia extract has remarkable potential to prevent obesity and associated metabolic disorders including the development of metabolic syndrome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.