ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2009
Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Role of Catalase C262T Gene Polymorphism in the Susceptibility and Survival of Cancers.Scientific reports · 2016Pooled it
- Occupational Lead Exposure and Associations with Selected Cancers: The Shanghai Men's and Women's Health Study Cohorts.Environmental health perspectives · 2016Pooled it
- Association between genetic variants in glutathione peroxidase 1 gene and risk of prostate cancer: a meta-analysis.Molecular biology reports · 2012Pooled it
- GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis.Journal of cancer research and clinical oncology · 2011Pooled it
- Survival of Laryngeal Cancer Patients Depending on Zinc Serum Level and Oxidative Stress Genotypes.Biomolecules · 2021Trial
- Serum xanthine oxidoreductase and oxidative stress are associated with bladder cancer: a case-control study from Jordan.Journal of applied biomedicine · 2025Article
- Current Understanding of Human Polymorphism in Selenoprotein Genes: A Review of Its Significance as a Risk Biomarker.International journal of molecular sciences · 2024Review
- MALDI Imaging Mass Spectrometry of High-Grade Gliomas: A Review of Recent Progress and Future Perspective.Current issues in molecular biology · 2023Review
- Review
- Covalent organic frameworks as multifunctional materials for chemical detection.Chemical Society reviews · 2021Review
- Article
- Development of Biopolymer and Conducting Polymer-Based Optical Sensors for Heavy Metal Ion Detection.Molecules (Basel, Switzerland) · 2020Review
- Genetic Factors of Nitric Oxide's System in Psychoneurologic Disorders.International journal of molecular sciences · 2020Review
- Fluorescent Sensors for the Detection of Heavy Metal Ions in Aqueous Media.Sensors (Basel, Switzerland) · 2019Review
- Chronic lead exposure induces cochlear oxidative stress and potentiates noise-induced hearing loss.Toxicology letters · 2018Article
- Use of MendelianFrontiers in genetics · 2018Review
- Interactions between occupational exposure to extremely low frequency magnetic fields and chemicals for brain tumour risk in the INTEROCC study.Occupational and environmental medicine · 2017Article
- New Opportunities in Exposure Assessment of Occupational Epidemiology: Use of Measurements to Aid Exposure Reconstruction in Population-Based Studies.Current environmental health reports · 2017Review
- Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case-control study.Environmental health : a global access science source · 2017Article
- Association between glutathione peroxidase-1 (GPX1) Rs1050450 polymorphisms and cancer risk.International journal of clinical and experimental pathology · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
There is some evidence that oxidative stress plays a role in lead-induced toxicity. Mechanisms for dealing with oxidative stress may be of particular relevance in the brain given the high rate of oxygen metabolism. Using a hospital-based case-control study, we investigated the role of oxidative stress in the potential carcinogenicity of lead through examination of effect modification of the association between occupational lead exposure and brain tumors by single nucleotide polymorphisms in genes with functions related to oxidative stress. The study included 362 patients with glioma (176 of which had glioblastoma multiforme), 134 patients with meningioma, and 494 controls. Lead exposure was estimated by expert review of detailed job history data for each participant. We evaluated effect modification with 142 single nucleotide polymorphisms using likelihood ratio tests that compared nested unconditional logistic regression models that did and did not include a cross-product term for cumulative lead exposure and genotype. When the analyses were restricted to cases with glioblastoma multiforme, RAC2 rs2239774 and two highly correlated GPX1 polymorphisms (rs1050450 and rs18006688) were found to significantly modify the association with lead exposure (P <or= 0.05) after adjustment for multiple comparisons. Furthermore, the same GPX1 polymorphisms and XDH rs7574920 were found to significantly modify the association between cumulative lead exposure and meningioma. Although the results of this study provide some evidence that lead may cause glioblastoma multiforme and meningioma through mechanisms related to oxidative damage, the results must be confirmed in other populations.
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