Evidence map›Paper›PMID 19505720›Full record

ArticleLeukemia research2010

Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: utility of fluorescence in situ hybridization (FISH) in a case-control study.

Cindy M Chang, Jane C Schroeder, Wen-Yi Huang, Cherie H Dunphy, Ralph S Baric, Andrew F Olshan, Kathleen C Dorsey, Georgette A Dent, James R Cerhan, Charles F Lynch and 3 more

Abstract readEvaluation Study
In one paragraph

Article in Leukemia research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. SEER cancer registry biospecimen research: yesterday and tomorrow.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cindy M ChangInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., EPS 7074, Rockville, MD 20892, USA. changcm@mail.nih.gov
Jane C Schroeder
Wen-Yi Huang
Cherie H Dunphy
Ralph S Baric
Andrew F Olshan
Kathleen C Dorsey
Georgette A Dent
James R Cerhan
Charles F Lynch
Nathaniel Rothman
Kenneth P Cantor
Aaron Blair

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Studies of Occupational CancerZIACP010120 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI LAN, QING · 2009 to 2025
$34.4M
Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
Epidemiology of Atypical Epstein-Barr Virus in LymphomaR21CA107966 · NCI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI SCHROEDER, JANE CLOWNEY · 2004 to 2005
$263k
EPIDEMIOLOGY OF T(14--18) IN NONHODGKINS LYMPHOMAR03CA071617 · NCI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI OLSHAN, ANDREW · 1996 to 1996
–
NCI NIH HHS R03 CA71617-01NCI NIH HHS R21 CA107966NICHD NIH HHS R24 HD050924NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30ES10126
6 · The paper itself

Abstract

We used fluorescence in situ hybridization (FISH) assays to identify t(14;18) translocations in archival paraffin-embedded tumor sections from non-Hodgkin lymphoma (NHL) cases enrolled in a population-based study. t(14;18) was identified in 54% of 152 cases, including 39% of diffuse large cell lymphomas (26 of 66 cases) and 84% of follicular lymphomas (36 of 43 cases). Eighty-seven percent of t(14;18)-positive cases and 57% of t(14;18)-negative cases expressed bcl-2. FISH assays detected twice as many t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes.

Indexed as

Translocation, GeneticCase-Control StudiesChromosomes, Human, Pair 14Chromosomes, Human, Pair 18HumansIn Situ Hybridization, FluorescenceLymphoma, FollicularLymphoma, Large B-Cell, DiffuseLymphoma, Non-HodgkinProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-bcl-2

Identifiers

PMID19505720
PMCPMC2815151

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.