ArticleNeuroImage2009
Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET.
Article in NeuroImage, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Combining brain perturbation and neuroimaging in non-human primates.NeuroImage · 2021Review
- Nonhuman Primate Models to Explore Mechanisms Underlying Early-Life Temperamental Anxiety.Biological psychiatry · 2021Review
- Serotonin Transporter Binding Potentials in Brain of Juvenile Monkeys 1 Year After Discontinuation of a 2-Year Treatment With Fluoxetine.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Functional Connectivity within the Primate Extended Amygdala Is Heritable and Associated with Early-Life Anxious Temperament.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Dispositional negativity: An integrative psychological and neurobiological perspective.Psychological bulletin · 2016Review
- Intergenerational neural mediators of early-life anxious temperament.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- 5-HTTLPR, anxiety and gender interaction moderates right amygdala volume in healthy subjects.Social cognitive and affective neuroscience · 2014Article
- Serotonin transporter genotype affects serotonin 5-HT1A binding in primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Acute responsivity of the serotonergic system to S-citalopram and positive emotionality-the moderating role of the 5-HTTLPR.Frontiers in human neuroscience · 2013Article
- Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Evidence for coordinated functional activity within the extended amygdala of non-human and human primates.NeuroImage · 2012Article
- Serotonergic modulation of conditioned fear.Scientifica · 2012Review
- Measures of anxiety, amygdala volumes, and hippocampal scopolamine phMRI response in elderly female rhesus macaques.Neuropharmacology · 2012Article
- The serotonin transporter gene polymorphism and the effect of baseline on amygdala response to emotional faces.Neuropsychologia · 2011Article
- Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission.Molecular psychiatry · 2010Article
- Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits.The American journal of psychiatry · 2010Review
- Serotonin, genetic variability, behaviour, and psychiatric disorders--a review.Upsala journal of medical sciences · 2010Review
- Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledThe length polymorphism of the serotonin (5-HT) transporter gene promoter region has been implicated in altered 5-HT function and, in turn, neuropsychiatric illnesses, such as anxiety and depression. The nonhuman primate has been used as a model to study anxiety-related mechanisms in humans based upon similarities in behavior and the presence of a similar 5-HT transporter gene polymorphism. Stressful and threatening contexts in the nonhuman primate model have revealed 5-HT transporter genotype dependent differences in regional glucose metabolism. Using the rhesus monkey, we examined the extent to which serotonin transporter genotype is associated with 5-HT transporter binding in brain regions implicated in emotion-related pathology.
methodsGenotype data and high resolution PET scans were acquired in 29 rhesus (Macaca mulatta) monkeys. [C-11]DASB dynamic PET scans were acquired for 90 min in the anesthetized animals and images of distribution volume ratio (DVR) were created to serve as a metric of 5-HT transporter binding for group comparison based on a reference region method of analysis. Regional and voxelwise statistical analysis were performed with corrections for anatomical differences in gray matter probability, sex, age and radioligand mass.
resultsThere were no significant differences when comparing l/l homozygotes with s-carriers in the regions of the brain implicated in anxiety and mood related illnesses (amygdala, striatum, thalamus, raphe nuclei, temporal and prefrontal cortex). There was a significant sex difference in 5-HT transporter binding in all regions with females having 18%-28% higher DVR than males.
conclusionsBecause these findings are consistent with similar genotype findings in humans, this further strengthens the use of the rhesus model for studying anxiety-related neuropathologies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.