ArticleDevelopmental biology2009
BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Pen-2 Negatively Regulates the Differentiation of Oligodendrocyte Precursor Cells into Astrocytes in the Central Nervous System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Mechanical Brain Injury Increases Cells' Production of Cystathionine β-Synthase and Glutamine Synthetase, but Reduces Pax2 Expression in the Telencephalon of Juvenile Chum Salmon,International journal of molecular sciences · 2021Article
- Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice.Investigative ophthalmology & visual science · 2020Article
- SMAD proteins directly suppressOncotarget · 2018Article
- Nuclear receptors in neural stem/progenitor cell homeostasis.Cellular and molecular life sciences : CMLS · 2017Review
- The Orphan Nuclear Receptor TLX/NR2E1 in Neural Stem Cells and Diseases.Neuroscience bulletin · 2016Review
- Nr2e1 Deficiency Augments Palmitate-Induced Oxidative Stress in Beta Cells.Oxidative medicine and cellular longevity · 2016Article
- Comparative analysis of glucagonergic cells, glia, and the circumferential marginal zone in the reptilian retina.The Journal of comparative neurology · 2016Article
- Sonic hedgehog patterning during cerebellar development.Cellular and molecular life sciences : CMLS · 2016Review
- TLX: A master regulator for neural stem cell maintenance and neurogenesis.Biochimica et biophysica acta · 2015Review
- Development of astrocytes in the vertebrate eye.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Histone deacetylase expression patterns in developing murine optic nerve.BMC developmental biology · 2014Article
- Bone morphogenetic protein 7 regulates reactive gliosis in retinal astrocytes and Müller glia.Molecular vision · 2014Article
- Orphan nuclear receptor TLX regulates astrogenesis by modulating BMP signaling.Frontiers in neuroscience · 2014Article
- Development and application of a next-generation-sequencing (NGS) approach to detect known and novel gene defects underlying retinal diseases.Orphanet journal of rare diseases · 2012Article
- Less expression of prohibitin is associated with increased paired box 2 (PAX2) in renal interstitial fibrosis rats.International journal of molecular sciences · 2012Article
- Embryonic stem cell-derived microvesicles induce gene expression changes in Müller cells of the retina.PloS one · 2012Article
- Comparative study of Pax2 expression in glial cells in the retina and optic nerve of birds and mammals.The Journal of comparative neurology · 2010Article
- Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Pax2 is essential for development of the neural tube, urogenital system, optic vesicle, optic cup and optic tract. In the eye, Pax2 deficiency is associated with coloboma, a loss of astrocytes in the optic nerve and retina, and abnormal axonal pathfinding of the ganglion cell axons at the optic chiasm. Thus, appropriate expression of Pax2 is essential for astrocyte determination and differentiation. Although BMP7 and SHH have been shown to regulate Pax2 expression, the molecular mechanism by which this regulation occurs is not well understood. In this study, we determined that BMP7 and SHH activate Pax2 expression in mouse retinal astrocyte precursors in vitro. SHH appeared to play a dual role in Pax2 regulation; 1) SHH may regulate BMP7 expression, and 2) the SHH pathway cooperates with the BMP pathway to regulate Pax2 expression. BMP and SHH pathway members can interact separately or together with TLX, a repressor protein in the tailless transcription factor family. Here we show that the interaction of both pathways with TLX relieves the repression of Pax2 expression in mouse retinal astrocytes. Together these data reveal a new mechanism for the cooperative actions of signaling pathways in astrocyte determination and differentiation and suggest interactions of regulatory pathways that are applicable to other developmental programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.