ArticleEpigenetics & chromatin2009
Tissue-specific variation in DNA methylation levels along human chromosome 1.
Article in Epigenetics & chromatin, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 67 citations in OpenAlex.
- Blood and adipose tissue DNA methylation in adults born preterm with a very low birth weight - a sibling comparison study.Epigenomics · 2026Article
- Methylation-based smoking signatures in blood and tissue samples for the prediction of self-reported smoking status and mortality in patients with colorectal cancer.Clinical epigenetics · 2025Article
- Large-scale integration of DNA methylation and gene expression array platforms identifies bothEpigenetics · 2022Article
- Article
- Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study.BMC pulmonary medicine · 2020Article
- Effects of PON1 Gene Promoter DNA Methylation and Genetic Variations on the Clinical Outcomes of Dual Antiplatelet Therapy for Patients Undergoing Percutaneous Coronary Intervention.Clinical pharmacokinetics · 2018Article
- Article
- Using Integrative Analysis of DNA Methylation and Gene Expression Data in Multiple Tissue Types to Prioritize Candidate Genes for Drug Development in Obesity.Frontiers in genetics · 2018Article
- Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.PloS one · 2018Article
- Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group.Environmental health perspectives · 2017Article
- Influence of maternal obesity on the long-term health of offspring.The lancet. Diabetes & endocrinology · 2017Review
- In silico analysis of regulatory and structural motifs of the ovine HSP90AA1 gene.Cell stress & chaperones · 2016Article
- Hypermethylation of RASAL1: A Key for Renal Fibrosis.EBioMedicine · 2015Article
- Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Epigenetic modification of FOXP3 in patients with chronic HIV infection.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Epigenetic regulation and measurement of epigenetic changes.Biological research for nursing · 2013Review
- Decreased expression of alpha-L-fucosidase gene FUCA1 in human colorectal tumors.International journal of molecular sciences · 2013Article
- DNA methylation and differentiation: HOX genes in muscle cells.Epigenetics & chromatin · 2013Article
- Epigenetics of progression of chronic kidney disease: fact or fantasy?Seminars in nephrology · 2013Review
- Concordance in hippocampal and fecal Nr3c1 methylation is moderated by maternal behavior in the mouse.Ecology and evolution · 2012Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundDNA methylation is a major epigenetic modification important for regulating gene expression and suppressing spurious transcription. Most methods to scan the genome in different tissues for differentially methylated sites have focused on the methylation of CpGs in CpG islands, which are concentrations of CpGs often associated with gene promoters.
resultsHere, we use a methylation profiling strategy that is predominantly responsive to methylation differences outside of CpG islands. The method compares the yield from two samples of size-selected fragments generated by a methylation-sensitive restriction enzyme. We then profile nine different normal tissues from two human donors relative to spleen using a custom array of genomic clones covering the euchromatic portion of human chromosome 1 and representing 8% of the human genome. We observe gross regional differences in methylation states across chromosome 1 between tissues from the same individual, with the most striking differences detected in the comparison of cerebellum and spleen. Profiles of the same tissue from different donors are strikingly similar, as are the profiles of different lobes of the brain. Comparing our results with published gene expression levels, we find that clones exhibiting extreme ratios reflecting low relative methylation are statistically enriched for genes with high expression ratios, and vice versa, in most pairs of tissues examined.
conclusionThe varied patterns of methylation differences detected between tissues by our methylation profiling method reinforce the potential functional significance of regional differences in methylation levels outside of CpG islands.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.