ReviewExpert review of cardiovascular therapy2009
Antihypertensive medications: benefits of blood pressure lowering and hazards of metabolic effects.
Review in Expert review of cardiovascular therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study.Diabetes · 2017Pooled it
- Cardiovascular Pharmacotherapy and Glucose Metabolism: The Good, the Bad and the Unsightly.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Review
- Impact of SGLT2 Inhibitors on Cardiovascular Risk Scores, Metabolic Parameters, and Laboratory Profiles in Type 2 Diabetes.Life (Basel, Switzerland) · 2025Article
- Role of the gut microbiome in cardiovascular drug response: The potential for clinical application.Pharmacotherapy · 2022Review
- Antihypertensive Effects of Aqueous Extract ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Visually guided classification trees for analyzing chronic patients.BMC bioinformatics · 2020Article
- Influence of pharmacological therapies on vascular function and urinary sodium/potassium excretion.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- A Validated RP-HPLC Stability Method for the Estimation of Chlorthalidone and Its Process-Related Impurities in an API and Tablet Formulation.International journal of analytical chemistry · 2020Article
- Antihypertensive effects of the hydro-ethanol extract of Senecio serratuloides DC in rats.BMC complementary and alternative medicine · 2019Article
- Country Characteristics and Variation in Diabetes Prevalence among Asian Countries - an Ecological Study.Journal of the ASEAN Federation of Endocrine Societies · 2019Article
- Comorbidity Status and Annual Total Medical Expenditures in U.S. Hypertensive Adults.American journal of preventive medicine · 2017Article
- Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity.Current gastroenterology reports · 2016Review
- Alteration in fasting glucose after prolonged treatment with a thiazide diuretic.Diabetes research and clinical practice · 2014Observational
- Anti-hypertensive drugs in children and adolescents.World journal of cardiology · 2014Review
- The metabolic cost of lowering blood pressure with hydrochlorothiazide.Diabetology & metabolic syndrome · 2013Article
- Antihypertensive drug class interactions and risk for incident diabetes: a nested case-control study.Journal of the American Heart Association · 2013Article
- A retrospective longitudinal cohort study of antihypertensive drug use and new-onset diabetes in Taiwanese patients.BioMed research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Blood pressure reduction is associated with significant reduction in adverse cardiovascular outcomes. Certain blood pressure-lowering drugs have adverse effects on glucose homeostasis, and have been associated with the development of both prediabetes and diabetes during use. There is controversy over the significance of diabetes that develops during treatment with antihypertensives and whether the benefits of blood pressure reduction offset the hazards of dysglycemia that can lead to diabetes. Many treatment guidelines have recently undergone revisions to include consideration for the metabolic effects of antihypertensive drugs, particularly in high-risk populations. This review summarizes the data related to the benefits of blood pressure reduction as well as the adverse metabolic effects and new-onset diabetes associated with some medications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.