ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Article
- Chinmo is a novel regulator of differential Hippo signaling response within a single developing organ.bioRxiv : the preprint server for biology · 2025Article
- B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity and Beyond.International journal of molecular sciences · 2024Review
- The Drosophila tumour suppressor Lgl and Vap33 activate the Hippo pathway through a dual mechanism.Journal of cell science · 2024Article
- Niche formation and function in developing tissue: studies from the Drosophila ovary.Cell communication and signaling : CCS · 2023Review
- Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L.Scientific reports · 2022Article
- Article
- Variation in Pleiotropic Hub Gene Expression Is Associated with Interspecific Differences in Head Shape and Eye Size in Drosophila.Molecular biology and evolution · 2021Article
- Genome-wide identification and gene-editing of pigment transporter genes in the swallowtail butterfly Papilio xuthus.BMC genomics · 2021Article
- Rounding up the Usual Suspects: Assessing Yorkie, AP-1, and Stat Coactivation in Tumorigenesis.International journal of molecular sciences · 2020Article
- Zika virus non-structural protein NS4A restricts eye growth inDisease models & mechanisms · 2020Article
- Next-Generation Sequencing Reveals Increased Anti-oxidant Response and Ecdysone Signaling in STAT Supercompetitors inG3 (Bethesda, Md.) · 2019Article
- Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity.Disease models & mechanisms · 2019Article
- Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'.Behavioral and brain functions : BBF · 2019Review
- JAK/STAT signaling in stem cells and regeneration: fromDevelopment (Cambridge, England) · 2019Review
- A Gene Expression Screen inG3 (Bethesda, Md.) · 2019Article
- Article
- Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps.BMC biology · 2017Article
- Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling.PLoS genetics · 2015Article
- BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila.PloS one · 2015Article
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4 authors.
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Abstract
Although the JAK/STAT pathway regulates numerous processes in vertebrates and invertebrates through modulating transcription, its functionally relevant transcriptional targets remain largely unknown. With one jak and one stat (stat92E), Drosophila provides a powerful system for finding new JAK/STAT target genes. Genome-wide expression profiling on eye discs in which Stat92E is hyperactivated, revealed 584 differentially regulated genes, including known targets domeless, socs36E, and wingless. Other differentially regulated genes (chinmo, lama, Mo25, Imp-L2, Serrate, Delta) were validated and may represent new Stat92E targets. Genetic experiments revealed that Stat92E cell-autonomously represses Serrate, which encodes a Notch ligand. Loss of Stat92E led to de-repression of Serrate in the dorsal eye, resulting in ectopic Notch signaling and aberrant eye growth there. Thus, our micro-array documents a new Stat92E target gene and a previously unidentified inhibitory action of Stat92E on Notch signaling. These data suggest that this study will be a useful resource for the identification of additional Stat92E targets.
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