Evidence map›Paper›PMID 19504359›Full record

ReviewClinical reviews in allergy & immunology2010

Chronic granulomatous disease.

Steven M Holland

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Clinical reviews in allergy & immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03055247 (A Multicentric, Exploratory, Non-randomised, Non-controlled, Prospective, Open-label Phase II Study Evaluating Safety and Efficacy of IBU, G-CSF and Plerixafor as Stem Cell Mobilization Regimen in Patients Affected by X-CGD), which is not on this map. Cited by 155 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03055247 phase2recruitingnot on this mapstarted 2015, after this paper: background citation

A Multicentric, Exploratory, Non-randomised, Non-controlled, Prospective, Open-label Phase II Study Evaluating Safety and Efficacy of IBU, G-CSF and Plerixafor as Stem Cell Mobilization Regimen in Patients Affected by X-CGD

TypeinterventionalSponsorIRCCS San RaffaeleRan2015 to 2026Enrolled3ConditionsChronic Granulomatous Disease X-linked (X-CGD)ArmsIbuprofen, Myelostim, Mozobil
3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Pioglitazone as a novel therapeutic approach in chronic granulomatous disease.The Journal of allergy and clinical immunology · 2016
    Trial
  3. First report ofMedical mycology case reports · 2026
    Article
  4. Innate immunity: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review
  5. How I Treat: Chronic granulomatous disease.Journal of human immunity · 2026
    Review
  6. Article
  7. Article
  8. Targeting respiratory virus-induced reactive oxygen species in airways diseases.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  9. Article
  10. Antibiotics (Basel, Switzerland) · 2025
    Review
  11. The pathobiology of human fungal infections.Nature reviews. Microbiology · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Phage therapy to treat cystic fibrosisFrontiers in microbiology · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Steven M HollandLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1684, USA. smh@nih.gov

Funding

Transgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2M
Intramural NIH HHS
6 · The paper itself

Abstract

Chronic granulomatous disease (CGD) was first described in the 1950s and has become a paradigm for genetic neutrophil diseases. It is characterized by recurrent infections with a narrow spectrum of bacteria and fungi as well as a common set of inflammatory complications most notably including inflammatory bowel disease. Over the last half century major advances in management have profoundly altered the major clinical issues and the life expectancy of CGD. With X-linked and autosomal recessive forms, it has been an important disease for the development of bone marrow transplantation and gene therapy. Some of the recent developments in infectious syndromes, inflammatory complications, and curative approaches are discussed in this review.

Indexed as

Granulomatous Disease, ChronicAnimalsAnti-Bacterial AgentsAntifungal AgentsBone Marrow TransplantationGenetic TherapyHumansInterferon-gammaMiceNADPH OxidasesAnti-Bacterial AgentsAntifungal AgentsInterferon-gammaNADPH Oxidases

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.