ArticleMolecular and cellular biochemistry2009
Up-regulation of orphan nuclear estrogen-related receptor alpha expression during long-term caloric restriction in mice.
Article in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Whole-genome sequencing GWAS reveals bovine genomic effects on enteric methane emissions in beef cattle.Scientific reports · 2025Article
- Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow.Nature communications · 2024Article
- Estrogen-related Receptor Signaling in Skeletal Muscle Fitness.International journal of sports medicine · 2023Article
- Review
- Estrogen-related receptor alpha in select host functions and cancer: new frontiers.Molecular and cellular biochemistry · 2022Review
- Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Article
- ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease.Frontiers in endocrinology · 2019Review
- Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice.PloS one · 2016Article
- Behavioral disturbances in estrogen-related receptor alpha-null mice.Cell reports · 2015Article
- The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases.Acta pharmacologica Sinica · 2015Review
- Eating disorder predisposition is associated with ESRRA and HDAC4 mutations.The Journal of clinical investigation · 2013Article
- Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.Frontiers in aging neuroscience · 2013Review
- Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism.PloS one · 2012Article
- Fasting induces the expression of PGC-1α and ERR isoforms in the outer stripe of the outer medulla (OSOM) of the mouse kidney.PloS one · 2011Article
- An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.Molecular endocrinology (Baltimore, Md.) · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The estrogen-related receptor alpha (ERRalpha) is an orphan receptor belonging to the nuclear receptor superfamily that regulates a number of target genes encoding enzymes that participate in various metabolic pathways involved in maintaining energy balance in animals. In this study, whether long-term caloric restriction (alternate days of fasting for 3 months) in mice modulates the expression of ERRalpha in various tissues was investigated. Western blot analyses showed positive immunoreactive ERRalpha protein (53 kDa) band in various mice tissue extracts, though at varying levels. Heart, kidney, and skeletal muscles expressed significant levels of ERRalpha, with a comparatively lower level detected in the intestine, brain, and liver. Cardiac ERRalpha expression was the highest, with the least detected in the liver. Caloric restricted mice exhibited a significant increase in ERRalpha level in the heart (5.45-fold), kidney (3.70-fold), skeletal muscle (3.0-fold), small intestine (2.72-fold), and liver (2.44-fold) extracts as compared to ad libitum fed. However, caloric restriction could not evoke any detectable receptor level change in the brain. Notably, the highest ERRalpha up-regulation was detected in the heart. This up-regulation in ERRalpha level especially in highly oxidative tissues such as heart, kidney, small intestine, and skeletal muscle of caloric restricted mice may be helpful in modulating ERRalpha responsive genes that participates in maintaining energy balance. This may potentially strengthen the metabolic and biochemical adaptation in such tissues, which is necessary for animal survival under long-term caloric restriction.
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