ArticlePloS one2009
Fgf and Sdf-1 pathways interact during zebrafish fin regeneration.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Temperature and photoperiod stress in zebrafish larvae: impacts on development, gene regulation and PGC migration.Fish physiology and biochemistry · 2025Article
- The influence of SDF-1 (CXCL12) gene in health and disease: a review of literature.Biophysical reviews · 2025Review
- wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Thyroid hormone regulates proximodistal patterning in fin rays.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming.The Journal of biological chemistry · 2019Article
- The CXCL12/CXCR4 Signaling Axis Retains Neutrophils at Inflammatory Sites in Zebrafish.Frontiers in immunology · 2019Article
- Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish.iScience · 2018Article
- A gene expression study of ornamental fin shape in Neolamprologus brichardi, an African cichlid species.Scientific reports · 2017Article
- CXCL12a/CXCR4b acts to retain neutrophils in caudal hematopoietic tissue and to antagonize recruitment to an injury site in the zebrafish larva.Immunogenetics · 2017Article
- Bmp signaling mediates endoderm pouch morphogenesis by regulating Fgf signaling in zebrafish.Development (Cambridge, England) · 2016Article
- A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration.PloS one · 2016Article
- The mammalian blastema: regeneration at our fingertips.Regeneration (Oxford, England) · 2015Review
- The art of fin regeneration in zebrafish.Regeneration (Oxford, England) · 2015Review
- Zebrafish keratocyte explants to study collective cell migration and reepithelialization in cutaneous wound healing.Journal of visualized experiments : JoVE · 2015Article
- sdf1 Expression reveals a source of perivascular-derived mesenchymal stem cells in zebrafish.Stem cells (Dayton, Ohio) · 2014Article
- Divergent requirements for fibroblast growth factor signaling in zebrafish maxillary barbel and caudal fin regeneration.Development, growth & differentiation · 2013Article
- Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed.Scientific reports · 2013Article
- Zebrafish models for ectopic mineralization disorders: practical issues from morpholino design to post-injection observations.Frontiers in genetics · 2013Article
- Developmental role of zebrafish protease-activated receptor 1 (PAR1) in the cardio-vascular system.PloS one · 2012Article
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Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chemokine stromal cell-derived factor-1 (SDF1) was originally identified as a pre-B cell stimulatory factor but has been recently implicated in several other key steps in differentiation and morphogenesis. In addition, SDF1 as well as FGF signalling pathways have recently been shown to be involved in the control of epimorphic regeneration. In this report, we address the question of a possible interaction between the two signalling pathways during adult fin regeneration in zebrafish. Using a combination of pharmaceutical and genetic tools, we show that during epimorphic regeneration, expression of sdf1, as well as of its cognate receptors, cxcr4a, cxcr4b and cxcr7 are controlled by FGF signalling. We further show that, Sdf1a negatively regulates the expression of fgf20a. Together, these results lead us to propose that: 1) the function of Fgf in blastema formation is, at least in part, relayed by the chemokine Sdf1a, and that 2) Sdf1 exerts negative feedback on the Fgf pathway, which contributes to a transient expression of Fgf20a downstream genes at the beginning of regeneration. However this feedback control can be bypassed since the Sdf1 null mutants regenerate their fin, though slower. Very few mutants for the regeneration process were isolated so far, illustrating the difficulty in identifying genes that are indispensable for regeneration. This observation supports the idea that the regeneration process involves a delicate balance between multiple pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.