ArticlePloS one2009
WNT/beta-catenin signalling and epithelial patterning in the homoscleromorph sponge Oscarella.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 86 citations in OpenAlex.
- Wnt signaling patterns a central-peripheral body axis in the early-diverging metazoan Trichoplax adhaerens.Molecular biology and evolution · 2026Article
- Targeting β-catenin: PROTACs and precision degraders for Wnt-driven cancers.Frontiers in oncology · 2026Review
- Article
- A transphyletic study of metazoan β-catenin protein complexes.Zoological letters · 2024Article
- The Buds of Oscarella lobularis (Porifera, Homoscleromorpha): A New Convenient Model for Sponge Cell and Evolutionary Developmental Biology.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Body-Plan Reorganization in a Sponge Correlates with Microbiome Change.Molecular biology and evolution · 2023Article
- Evolution of mechanisms controlling epithelial morphogenesis across animals: new insights from dissociation-reaggregation experiments in the sponge Oscarella lobularis.BMC ecology and evolution · 2021Article
- In Situ Hybridization Techniques in the Homoscleromorph Sponge Oscarella lobularis.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Article
- Wnt signaling and polarity in freshwater sponges.BMC evolutionary biology · 2018Article
- Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development.PLoS biology · 2018Article
- Phylogenetic evidence for the modular evolution of metazoan signalling pathways.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Evolution of the NET (NocA, Nlz, Elbow, TLP-1) protein family in metazoans: insights from expression data and phylogenetic analysis.Scientific reports · 2016Article
- Surprisingly rich repertoire of Wnt genes in the demosponge Halisarca dujardini.BMC evolutionary biology · 2016Article
- TCF/Lef regulates the Gsx ParaHox gene in central nervous system development in chordates.BMC evolutionary biology · 2016Article
- Oscarella lobularis (Homoscleromorpha, Porifera) Regeneration: Epithelial Morphogenesis and Metaplasia.PloS one · 2015Article
- Disulfide bond requirements for active Wnt ligands.The Journal of biological chemistry · 2014Article
- Cellular and molecular processes leading to embryo formation in sponges: evidences for high conservation of processes throughout animal evolution.Development genes and evolution · 2013Review
- Systematics and molecular phylogeny of the family oscarellidae (homoscleromorpha) with description of two new oscarella species.PloS one · 2013Article
- A small molecule inhibitor of SRC family kinases promotes simple epithelial differentiation of human pluripotent stem cells.PloS one · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sponges branch basally in the metazoan phylogenetic tree and are thus well positioned to provide insights into the evolution of mechanisms controlling animal development, likely to remain active in adult sponges. Of the four sponge clades, the Homoscleromorpha are of particular interest as they alone show the "true" epithelial organization seen in other metazoan phyla (the Eumetazoa). We have examined the deployment in sponges of Wnt signalling pathway components, since this pathway is an important regulator of many developmental patterning processes. We identified a reduced repertoire of three divergent Wnt ligand genes in the recently-sequenced Amphimedon queenslandica (demosponge) genome and two Wnts from our EST collection from the homoscleromorph Oscarella lobularis, along with well-conserved genes for intracellular pathway components (beta-catenin, GSK3beta). Remarkably, the two O. lobularis Wnt genes showed complementary expression patterns in relation to the evenly spaced ostia (canal openings) of the exopinacoderm (ectoderm), highly reminiscent of Wnt expression during skin appendage formation in vertebrates. Furthermore, experimental activation of the Wnt/beta-catenin pathway using GSK3beta inhibitors provoked formation of ectopic ostia, as has been shown for epithelial appendages in Eumetazoa. We thus suggest that deployment of Wnt signalling is a common and perhaps ancient feature of metazoan epithelial patterning and morphogenesis.
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