ReviewClinical interventions in aging2009
Use of anticoagulants in elderly patients: practical recommendations.
Review in Clinical interventions in aging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03647254 (Effectivity of a Joint Didactic Intervention by School for Patients on Inappropriate Control Prothrombin Time Anticoagulated Patients. Protocol for Developing a Randomized and Controlled Clinical Trial), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectivity of a Joint Didactic Intervention by School for Patients on Inappropriate Control Prothrombin Time Anticoagulated Patients. Protocol for Developing a Randomized and Controlled Clinical Trial
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Risk factors for neck hematoma requiring surgical re-intervention after thyroidectomy: a systematic review and meta-analysis.BMC surgery · 2019Pooled it
- Hospital admissions due to adverse drug reactions in the elderly. A meta-analysis.European journal of clinical pharmacology · 2017Pooled it
- A French multicenter randomised trial comparing two dose-regimens of prothrombin complex concentrates in urgent anticoagulation reversal.Critical care (London, England) · 2013Trial
- Disproportionality analysis of fondaparinux associated adverse events based on the FDA adverse event reporting system.PloS one · 2026Article
- Elderly coagulation risk in a globalized world: burden, biomarkers, and management in Africa - a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Article
- Proximal Tibia Fractures in Osteoporosis.Indian journal of orthopaedics · 2025Review
- Real-World Effectiveness, Safety, and Tolerability of Facilitated Subcutaneous Immunoglobulin 10% in Secondary Immunodeficiency Disease: A Systematic Literature Review.Journal of clinical medicine · 2025Review
- Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort study.BMC geriatrics · 2024Observational
- Catheter-Directed Interventions for the Treatment of Lower Extremity Deep Vein Thrombosis.Life (Basel, Switzerland) · 2022Review
- Haemorrhagic complications in patients with renal insufficiency during treatment or prophylaxis with dalteparin.European journal of hospital pharmacy : science and practice · 2022Article
- Article
- Factors influencing activated clotting time following heparin administration for the initiation of cardiopulmonary bypass.General thoracic and cardiovascular surgery · 2021Article
- Inclusion of medication-related fall risk in fall risk assessment tool in geriatric care units.BMC geriatrics · 2020Article
- Current Update on Treatment Strategies for Idiopathic Normal Pressure Hydrocephalus.Current treatment options in neurology · 2019Review
- Follow-up and management of valvular heart disease patients with prosthetic valve: a clinical practice guideline for Indian scenario.Indian journal of thoracic and cardiovascular surgery · 2019Article
- Enoxaparin 20 mg for thromboprophylaxis in severe renal impairment.The Journal of international medical research · 2019Article
- Delayed intracranial hemorrhage in elderly anticoagulated patients sustaining a minor fall.BMC emergency medicine · 2018Article
- Prothrombin Complex Concentrate Reversal of Coagulopathy in Emergency General Surgery Patients.World journal of surgery · 2018Article
- Antiplatelet and Anticoagulant Medications Significantly Increase the Risk of Postoperative Hematoma: Review of over 4500 Thyroid and Parathyroid Procedures.Annals of surgical oncology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elderly people represent a patient population at high thromboembolic risk, but also at high hemorrhagic risk. There is a general tendency among physicians to underuse anticoagulants in the elderly, probably both because of underestimation of thromboembolic risk and overestimation of bleeding risk. The main indications for anticoagulation are venous thromboembolism (VTE) prophylaxis in medical and surgical settings, VTE treatment, atrial fibrillation (AF) and valvular heart disease. Available anticoagulants for VTE prophylaxis and initial treatment of VTE are low molecular weight heparins (LMWH), unfractionated heparin (UFH) or synthetic anti-factor Xa pentasaccharide fondaparinux. For long-term anticoagulation vitamin K antagonists (VKA) are the first choice and only available oral anticoagulants nowadays. Assessing the benefit-risk ratio of anticoagulation is one of the most challenging issues in the individual elderly patient, patients at highest hemorrhagic risk often being those who would have the greatest benefit from anticoagulants. Some specific considerations are of utmost importance when using anticoagulants in the elderly to maximize safety of these treatments, including decreased renal function, co-morbidities and risk of falls, altered pharmacodynamics of anticoagulants especially VKAs, association with antiplatelet agents, patient education. Newer anticoagulants that are currently under study could simplify the management and increase the safety of anticoagulation in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.