ArticleMolecular vision2009
Association of LOXL1 polymorphisms with pseudoexfoliation in the Chinese.
Article in Molecular vision, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- LOXL1 gene polymorphisms are associated with exfoliation syndrome/exfoliation glaucoma risk: An updated meta-analysis.PloS one · 2021Pooled it
- Pooled it
- Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma.Molecular vision · 2010Pooled it
- Exfoliation Syndrome in a Large Vietnamese American Clinic Population: Clinical Characteristics Including Prevalence of Glaucoma and Narrow Angles.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Metabolomic Signatures and Predictive Utility ofMetabolites · 2025Article
- Modeling complex age-related eye disease.Progress in retinal and eye research · 2024Review
- Inhibitory and Agonistic Autoantibodies Directed Against the βFrontiers in neuroscience · 2021Article
- Review
- Association ofIranian journal of public health · 2019Article
- Three Single Nucleotide Polymorphisms ofTurkish journal of ophthalmology · 2018Article
- Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms.Journal of ophthalmology · 2018Review
- Association ofInternational journal of ophthalmology · 2018Article
- Lysyl oxidase-like 1 polymorphisms in a southwestern Greek cataract population with pseudoexfoliation syndrome.Clinical ophthalmology (Auckland, N.Z.) · 2016Article
- LOXL1 gene variants and their association with pseudoexfoliation glaucoma (XFG) in Spanish patients.BMC medical genetics · 2015Article
- Pseudoexfoliation syndrome at a Singapore eye clinic.Clinical ophthalmology (Auckland, N.Z.) · 2015Article
- The association of LOXL1 polymorphisms with exfoliation syndrome/glaucoma: Meta-analysis.International journal of ophthalmology · 2015Article
- Lysyl oxidase-like 1 gene in the reversal of promoter risk allele in pseudoexfoliation syndrome.JAMA ophthalmology · 2014Article
- Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population.Scientific reports · 2014Article
- Association of lysyl oxidase-like 1 gene common sequence variants in Greek patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.Molecular vision · 2013Article
- Evaluation of lysyl oxidase-like 1 gene polymorphisms in pseudoexfoliation syndrome in a Korean population.Molecular vision · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSingle nucleotide polymorphisms (SNPs) within the lysyl oxidase like-1 gene (LOXL1; rs1048661 and rs3825942) were found to confer risk to pseudoexfoliation glaucoma (XFG) through the pseudoexfoliation syndrome (XFS) in Nordic, Caucasian, and two Asiatic populations (Indian and Japanese). The prevalence (0.2%-0.7%) of XFS in the Chinese is considerably lower compared to Nordic populations. The aim of this study was to determine the association of LOXL1 in Chinese subjects with XFS/XFG.
methodsChinese subjects with clinically diagnosed XFS/XFG and normal controls were recruited. Genomic DNA was extracted, and the two LOXL1 SNPs (rs1048661 and rs3825942) were genotyped by bidirectional sequencing. Allele and genotype frequencies were compared between cases and unrelated controls using PLINK. Linkage disequilibrium (LD) calculations and haplotype association analysis were done using the Haploview package and WHAP package, respectively.
resultsSixty-two Chinese patients (17 XFG and 45 XFS) and 171 Chinese controls were studied. The G allele of LOXL1 SNP rs3825942 was moderately associated (OR=10.97, p=0.0018) with pseudoxfoliation in the Chinese. The frequency of the G allele of rs1048661 was not significantly different in cases compared to controls (p=0.142) in the allelic association test. However, the genotype test showed marginal association for rs1048661 (p=0.030). Only three haplotypes were observed (T-G, G-G, and G-A) with G-G as a risk haplotype (p=0.0034) and G-A as a protective haplotype (p=0.00039). T-G, which was a risk haplotype in the Japanese, was not associated with XFG in the Chinese (p=0.124).
conclusionsPolymorphisms in LOXL1 confer risk to XFS/XFG in the Chinese. The lower incidence of XFS compared to other populations suggests additional genetic or environmental factors to have a major influence on the phenotypic expression of XFS in the Chinese. The G allele of rs3825942 has been shown to be associated with XFS/XFG in all populations studied to date.
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19503743PMC2690963W1611315021What OpenQuestion holds
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