ArticlePLoS pathogens2009
Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees.
Article in PLoS pathogens, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
104 citing papers in PubMed, 230 citations in OpenAlex.
- The LncRNA Expression Profile and Regulatory Network of Microsporidian During the Infection of Western Honeybee.Animals : an open access journal from MDPI · 2026Article
- A miR-JL-5 inhibitor modulates the proliferation ofFrontiers in insect science · 2025Article
- Genome Structure, Evolution, and Host Shift ofBiology · 2024Article
- NcPTP2, a polar tube protein, interacts with spore wall protein in the parasitic microsporidian Nosema ceranae.Molecular biology reports · 2024Article
- Disentangling cobionts and contamination in long-read genomic data using sequence composition.G3 (Bethesda, Md.) · 2024Article
- Article
- Revealing the genome of the microsporidian Vairimorpha bombi, a potential driver of bumble bee declines in North America.G3 (Bethesda, Md.) · 2024Article
- MicroAnnot: A Dedicated Workflow for Accurate Microsporidian Genome Annotation.International journal of molecular sciences · 2024Article
- Biogenesis, inheritance, and 3D ultrastructure of the microsporidian mitosome.Life science alliance · 2024Article
- Widespread infection, diversification and old host associations of Nosema Microsporidia in European freshwater gammarids (Amphipoda).PLoS pathogens · 2023Article
- Geographic population structure of the honeybee microsporidian parasite Vairimorpha (Nosema) ceranae in the South West Indian Ocean.Scientific reports · 2023Article
- Engineered symbiotic bacteria interfering Nosema redox system inhibit microsporidia parasitism in honeybees.Nature communications · 2023Article
- New insights into the genome and transmission of the microsporidian pathogenFrontiers in microbiology · 2023Article
- Transcriptome ofInsects · 2022Article
- Molecular Detection and Differentiation of Arthropod, Fungal, Protozoan, Bacterial and Viral Pathogens of Honeybees.Veterinary sciences · 2022Review
- In-depth investigation of microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian.Frontiers in microbiology · 2022Article
- The Function and Structure of the Microsporidia Polar Tube.Experientia supplementum (2012) · 2022Article
- Impact of Genome Reduction in Microsporidia.Experientia supplementum (2012) · 2022Article
- Comparative Genomics of Microsporidia.Experientia supplementum (2012) · 2022Article
- Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Recent steep declines in honey bee health have severely impacted the beekeeping industry, presenting new risks for agricultural commodities that depend on insect pollination. Honey bee declines could reflect increased pressures from parasites and pathogens. The incidence of the microsporidian pathogen Nosema ceranae has increased significantly in the past decade. Here we present a draft assembly (7.86 MB) of the N. ceranae genome derived from pyrosequence data, including initial gene models and genomic comparisons with other members of this highly derived fungal lineage. N. ceranae has a strongly AT-biased genome (74% A+T) and a diversity of repetitive elements, complicating the assembly. Of 2,614 predicted protein-coding sequences, we conservatively estimate that 1,366 have homologs in the microsporidian Encephalitozoon cuniculi, the most closely related published genome sequence. We identify genes conserved among microsporidia that lack clear homology outside this group, which are of special interest as potential virulence factors in this group of obligate parasites. A substantial fraction of the diminutive N. ceranae proteome consists of novel and transposable-element proteins. For a majority of well-supported gene models, a conserved sense-strand motif can be found within 15 bases upstream of the start codon; a previously uncharacterized version of this motif is also present in E. cuniculi. These comparisons provide insight into the architecture, regulation, and evolution of microsporidian genomes, and will drive investigations into honey bee-Nosema interactions.
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Registered trials
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