ArticlePLoS genetics2009
The impact of divergence time on the nature of population structure: an example from Iceland.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 6 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Pooled it
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- Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.Nature genetics · 2023Pooled it
- A large-scale genome-wide association study meta-analysis of cannabis use disorder.The lancet. Psychiatry · 2020Pooled it
- HLA class II sequence variants influence tuberculosis risk in populations of European ancestry.Nature genetics · 2016Pooled it
- Replicability and robustness of genome-wide-association studies for behavioral traits.Psychological science · 2014Pooled it
- The genetic architecture of fibromyalgia across 2.5 million individuals.Nature medicine · 2026Article
- The genetic architecture of fibromyalgia across 2.5 million individuals.medRxiv : the preprint server for health sciences · 2025Article
- Obesity Variants in the GIPR Gene Are not Associated With Risk of Fracture or Bone Mineral Density.The Journal of clinical endocrinology and metabolism · 2024Article
- Inference of Locus-Specific Population Mixtures from Linked Genome-Wide Allele Frequencies.Molecular biology and evolution · 2024Article
- Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura.Nature genetics · 2023Article
- Screening for Rare Coding Variants That Associate With the QTc Interval in Iceland.Journal of the American Heart Association · 2023Article
- Odontostomatological Traits in North-Eastern Italy's Isolated Populations: An Epidemiological Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.Scientific reports · 2022Article
- Description of a Lung Cancer Hotspot: Disparities in Lung Cancer Histology, Incidence, and Survival in Kentucky and Appalachian Kentucky.Clinical lung cancer · 2021Article
- The genetic structure of Norway.European journal of human genetics : EJHG · 2021Article
- SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control study.BMC psychiatry · 2019Article
- Signals Among Signals: Prioritizing Nongenetic Associations in Massive Data Sets.American journal of epidemiology · 2019Article
- Analysis of type 2 diabetes and obesity genetic variants in Mexican Pima Indians: Marked allelic differentiation among Amerindians at HLA.Annals of human genetics · 2018Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The Icelandic population has been sampled in many disease association studies, providing a strong motivation to understand the structure of this population and its ramifications for disease gene mapping. Previous work using 40 microsatellites showed that the Icelandic population is relatively homogeneous, but exhibits subtle population structure that can bias disease association statistics. Here, we show that regional geographic ancestries of individuals from Iceland can be distinguished using 292,289 autosomal single-nucleotide polymorphisms (SNPs). We further show that subpopulation differences are due to genetic drift since the settlement of Iceland 1100 years ago, and not to varying contributions from different ancestral populations. A consequence of the recent origin of Icelandic population structure is that allele frequency differences follow a null distribution devoid of outliers, so that the risk of false positive associations due to stratification is minimal. Our results highlight an important distinction between population differences attributable to recent drift and those arising from more ancient divergence, which has implications both for association studies and for efforts to detect natural selection using population differentiation.
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