ArticleCell cycle (Georgetown, Tex.)2009
Identification of new Rel/NFkappaB regulatory networks by focused genome location analysis.
Article in Cell cycle (Georgetown, Tex.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
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- Dietary Protection against Cognitive Impairment, Neuroinflammation and Oxidative Stress in Alzheimer's Disease Animal Models of Lipopolysaccharide-Induced Inflammation.International journal of molecular sciences · 2023Review
- An Expanded Interplay Network between NF-κB p65 (RelA) and E2F1 Transcription Factors: Roles in Physiology and Pathology.Cancers · 2022Article
- Article
- Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway.Cell death and differentiation · 2021Article
- CiRS-7 targeting miR-7 modulates the progression of non-small cell lung cancer in a manner dependent on NF-κB signalling.Journal of cellular and molecular medicine · 2018Article
- CRISPR/Cas9-mediated knockout of c-REL in HeLa cells results in profound defects of the cell cycle.PloS one · 2017Article
- Article
- Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation.Journal of leukocyte biology · 2013Review
- NFκB function and regulation in cutaneous T-cell lymphoma.American journal of cancer research · 2013Review
- BRCA1 and p53 regulate critical prostate cancer pathways.Prostate cancer and prostatic diseases · 2013Article
- Comparative analysis of bat genomes provides insight into the evolution of flight and immunity.Science (New York, N.Y.) · 2013Article
- Overrepresentation of transcription factor families in the genesets underlying breast cancer subtypes.BMC genomics · 2012Article
- CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage.Nucleic acids research · 2012Article
- NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes.Nucleic acids research · 2012Article
- GPMiner: an integrated system for mining combinatorial cis-regulatory elements in mammalian gene group.BMC genomics · 2012Article
- A key role for NF-κB transcription factor c-Rel in T-lymphocyte-differentiation and effector functions.Clinical & developmental immunology · 2012Review
- Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2012Article
- BRCA1 loss induces GADD153-mediated doxorubicin resistance in prostate cancer.Molecular cancer research : MCR · 2011Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
NFkappaB is an inducible transcription factor that controls kinetically complex patterns of gene expression. Several studies reveal multiple pathways linking NFkappaB to the promotion and progression of various cancers. Despite extensive interest and characterization, many NFkappaB controlled genes still remain to be identified. We used chromatin immunoprecipitation combined with microarray technology (ChIP/chip) to investigate the dynamic interaction of NFkappaB with the promoter regions of 100 genes known to be expressed in mitogen-induced T-cells. Six previously unrecognized NFkappaB controlled genes (ATM, EP300, TGFbeta, Selectin, MMP-1 and SFN) were identified. Each gene is induced in mitogen-stimulated T-cells, repressed by pharmacological NFkappaB blockade, reduced in cells deficient in the p50 NFkappaB subunit and dramatically repressed by RNAi specifically designed against cRel. A coregulatory role for Ets transcription factors in the expression of the NFkappaB controlled genes was predicted by comparative promoter analysis and confirmed by ChIP and by functional disruption of Ets. NFkappaB deficiency produces a deficit in ATM function and DNA repair indicating an active role for NFkappaB in maintaining DNA integrity. These results define new potential targets and transcriptional networks governed by NFkappaB and provide novel functional insights for the role of NFkappaB in genomic stability, cell cycle control, cell-matrix and cell-cell interactions during tumor progression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.