ArticleEukaryotic cell2009
A pathogenesis assay using Saccharomyces cerevisiae and Caenorhabditis elegans reveals novel roles for yeast AP-1, Yap1, and host dual oxidase BLI-3 in fungal pathogenesis.
Article in Eukaryotic cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 59 citations in OpenAlex.
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- Non-Saccharomyces yeasts contribute to longevity, mitigated protein toxicity, and protection against abiotic stress in Caenorhabditis elegans.Archives of microbiology · 2026Article
- Shaker/Kv1 potassium channel SHK-1 protects against pathogen infection and oxidative stress in C. elegans.PLoS genetics · 2025Article
- Bite size ofJournal of biosciences · 2025Article
- Oxidative stress response pathways in fungi.Cellular and molecular life sciences : CMLS · 2022Review
- The gut efflux pump MRP-1 exports oxidized glutathione as a danger signal that stimulates behavioral immunity and aversive learning.Communications biology · 2022Article
- Novel Nematode-Killing Protein-1 (Nkp-1) from a Marine Epiphytic BacteriumBiomedicines · 2021Article
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- Innate immunity in C. elegans.Current topics in developmental biology · 2021Review
- Virulence phenotypes result from interactions between pathogen ploidy and genetic background.Ecology and evolution · 2020Article
- Investigation into In Vitro and In VivoMicroorganisms · 2020Article
- Probiotic Yeasts Inhibit Virulence of NonmBio · 2019Article
- Filamentation Regulatory Pathways Control Adhesion-Dependent Surface Responses in Yeast.Genetics · 2019Article
- A Novel Virulence Phenotype Rapidly AssessesmSphere · 2019Article
- Review
- Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging.Antioxidants (Basel, Switzerland) · 2018Review
- Genome-Wide Screen forG3 (Bethesda, Md.) · 2018Article
- The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions.Journal of visualized experiments : JoVE · 2017Article
- Caenorhabditis elegans as a model for understanding ROS function in physiology and disease.Redox biology · 2017Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment of systemic fungal infections is difficult because of the limited number of antimycotic drugs available. Thus, there is an immediate need for simple and innovative systems to assay the contribution of individual genes to fungal pathogenesis. We have developed a pathogenesis assay using Caenorhabditis elegans, an established model host, with Saccharomyces cerevisiae as the invading fungus. We have found that yeast infects nematodes, causing disease and death. Our data indicate that the host produces reactive oxygen species (ROS) in response to fungal infection. Yeast mutants sod1Delta and yap1Delta, which cannot withstand ROS, fail to cause disease, except in bli-3 worms, which carry a mutation in a dual oxidase gene. Chemical inhibition of the NADPH oxidase activity abolishes ROS production in worms exposed to yeast. This pathogenesis assay is useful for conducting systematic, whole-genome screens to identify fungal virulence factors as alternative targets for drug development and exploration of host responses to fungal infections.
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