ArticleDiabetes2009
Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity.
Article in Diabetes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 79 citations in OpenAlex.
- Enhanced BMP Signaling Alters Human β-Cell Identity and Function.Advanced biology · 2025Article
- Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding.Cell death & disease · 2023Article
- Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow.Science advances · 2022Article
- Genome-wide DNA methylation profiling in anorexia nervosa discordant identical twins.Translational psychiatry · 2022Article
- The TGF-β ligand DBL-1 is a key player in a multifaceted probiotic protection against MRSA in C. elegans.Scientific reports · 2021Article
- Iron Metabolism in Obesity and Metabolic Syndrome.International journal of molecular sciences · 2020Review
- Genetically programmed changes in transcription of the novel progranulin regulator.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Article
- Association of circulating BMP9 with coronary heart disease and hypertension in Chinese populations.BMC cardiovascular disorders · 2019Article
- Beyond the bone: Bone morphogenetic protein signaling in adipose tissue.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019Review
- Increased BMPR1A Expression Enhances the Adipogenic Differentiation of Mesenchymal Stem Cells in Patients with Ankylosing Spondylitis.Stem cells international · 2019Article
- TGF-β Family Signaling in Mesenchymal Differentiation.Cold Spring Harbor perspectives in biology · 2018Review
- Subcutaneous adipose tissue gene expression and DNA methylation respond to both short- and long-term weight loss.International journal of obesity (2005) · 2018Article
- IL-6 potentiates BMP-2-induced osteogenesis and adipogenesis via two different BMPR1A-mediated pathways.Cell death & disease · 2018Article
- Article
- BMPs as new insulin sensitizers: enhanced glucose uptake in mature 3T3-L1 adipocytes via PPARγ and GLUT4 upregulation.Scientific reports · 2017Article
- Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A.Endocrinology · 2017Article
- Combined GWAS and 'guilt by association'-based prioritization analysis identifies functional candidate genes for body size in sheep.Genetics, selection, evolution : GSE · 2017Article
- Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance.Diabetologia · 2016Article
- Enrichment of Adipose-Derived Stromal Cells for BMPR1A Facilitates Enhanced Adipogenesis.Tissue engineering. Part A · 2016Article
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Authors and funding
19 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveMembers of the family of bone morphogenetic proteins (BMPs) are important regulators of adipogenesis. We examined the role of the BMP receptor 1A gene (BMPR1A) in the pathophysiology of human obesity. RESEARCH DESIGN AND
methodsWe measured BMPR1A mRNA expression in paired samples of visceral and subcutaneous adipose tissue from 297 subjects and sequenced the BMPR1A in 48 nonrelated white subjects. Twenty-one representative variants including HapMap tagging single nucleotide polymorphisms (SNPs) were then genotyped for association studies in German whites (n = 1,907). For replication analyses, we used a population of Sorbs from Germany (n = 900) and German childhood cohorts (n = 1,029 schoolchildren and 270 obese children).
resultsmRNA expression of the BMPR1A was significantly increased in both visceral and subcutaneous adipose tissue of overweight and obese subjects compared with lean subjects (P < 0.05). In a case-control study, four SNPs (rs7095025, rs11202222, rs10788528, and rs7922846) were nominally associated with obesity (adjusted P < 0.05). For three SNPs (rs7095025, rs11202222, and rs10788528), the association with obesity was confirmed in the independent cohort of Sorbs (adjusted P < 0.005). Consistent with this, BMPR1A SNPs were nominally associated with obesity-related quantitative traits in nondiabetic subjects in both adult cohorts. Furthermore, homozygous carriers of the obesity risk alleles had higher BMPR1A mRNA expression in fat than noncarriers.
conclusionsOur data suggest that genetic variation in the BMPR1A may play a role in the pathophysiology of human obesity, possibly mediated through effects on mRNA expression.
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