ArticleMolecular immunology2009
Ragweed pollen-mediated IgE-independent release of biogenic amines from mast cells via induction of mitochondrial dysfunction.
Article in Molecular immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model.Journal of the Royal Society, Interface · 2014Trial
- Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes.The Journal of biological chemistry · 2012Trial
- Crosstalk Between Allergic Inflammation and Autophagy.International journal of molecular sciences · 2025Review
- Oxidative Stress and Mitochondria Are Involved in Anaphylaxis and Mast Cell Degranulation: A Systematic Review.Antioxidants (Basel, Switzerland) · 2024Review
- Multi-omics-based identification of atopic dermatitis target genes and their potential associations with metabolites and miRNAs.American journal of translational research · 2021Article
- Mitochondrial dysfunction in lung ageing and disease.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Modulation of Mast Cell Reactivity by Lipids: The Neglected Side of Allergic Diseases.Frontiers in immunology · 2019Review
- Elucidating novel disease mechanisms in severe asthma.Clinical & translational immunology · 2016Review
- Mitochondria in lung disease.The Journal of clinical investigation · 2016Review
- Pathophysiology of bronchoconstriction: role of oxidatively damaged DNA repair.Current opinion in allergy and clinical immunology · 2016Review
- The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma.Mediators of inflammation · 2016Review
- Integrating mitochondriomics in children's environmental health.Journal of applied toxicology : JAT · 2015Review
- Innate responses to pollen allergens.Current opinion in allergy and clinical immunology · 2015Review
- Inhaled environmental allergens and toxicants as determinants of the asthma phenotype.Advances in experimental medicine and biology · 2014Review
- Mast cell-deficient kit mice develop house dust mite-induced lung inflammation despite impaired eosinophil recruitment.Journal of innate immunity · 2014Article
- Pharmacological potential of biogenic amine-polyamine interactions beyond neurotransmission.British journal of pharmacology · 2013Review
- Mitochondrial dysfunction in metabolic syndrome and asthma.Journal of allergy · 2013Article
- New insights into an old story: pollen ROS also play a role in hay fever.Plant signaling & behavior · 2012Review
- Targeting cardiac mast cells: pharmacological modulation of the local renin-angiotensin system.Current pharmaceutical design · 2011Review
- Mountain cedar pollen induces IgE-independent mast cell degranulation, IL-4 production, and intracellular reactive oxygen species generation.Cellular immunology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Normal functions of mitochondria are required for physiological dynamics of cells, while their dysfunction contributes to development of various disorders including those of immune system. Here we demonstrate that exposure of mast cells to ragweed pollen extract increases production of H(2)O(2) via mitochondrial respiratory complex III. These mitochondrial ROS (mtROS) enhance secretion of histamine and serotonin from mast cells, but not enzymes such as beta-hexosaminidase, independently from FcvarepsilonRI-generated stimuli. The release of biogenic amines is associated with inhibition of secretory granules' H(+)-ATPase activity, activation of PKC-delta and microtubule-dependent motility, and it is independent from intracellular free Ca(2+) levels. To asses differences from IgE-mediated mast cell degranulation we show that mtROS decrease antigen-triggered beta-hexosaminidase release, while they are synergistic with antigen-induced IL-4 production in sensitized cells. Taken together, these data indicate that mitochondrial dysfunction can act independently from adaptive immunity, as well as augments Th2-type responses. Pharmacological maintenance of physiological mitochondrial function could have clinical benefits in prevention and treatment of allergic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.