Evidence map›Paper›PMID 19501669›Full record

ReviewProgress in retinal and eye research2009

Structure of cone photoreceptors.

Debarshi Mustafi, Andreas H Engel, Krzysztof Palczewski

Abstract readReview
In one paragraph

Review in Progress in retinal and eye research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 262 citations in OpenAlex.

  1. Trial
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  4. Review
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  7. Review
  8. DownregulatingInternational journal of molecular sciences · 2026
    Article
  9. Review
  10. S-Cone Retinal Pathway Dysfunction in Myopia.Investigative ophthalmology & visual science · 2026
    Article
  11. Gene therapy rescues cone function inMolecular therapy. Advances · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Factors affecting color vision: a systematic review.International journal of ophthalmology · 2026
    Review
  19. Review
  20. Article

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Debarshi MustafiDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH 44106-4965, USA.
Andreas H Engel
Krzysztof Palczewski
Case Western Reserve University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
STRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0M
VISUAL SCIENCES TRAINING PROGRAMT32EY007157 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Johannes Friedrich von Lintig · 2000 to 2026
$5.5M
Structural dissection of the visual signaling network in cone cellsR01EY019478 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI ENGEL, ANDREAS HERMANN, PALCZEWSKI, KRZYSZTOF · 2009 to 2013
$1.9M
STRUCTURAL STUDIES OF G PROTEIN-COUPLED RECEPTORSR01GM079191 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI PALCZEWSKI, KRZYSZTOF · 2007 to 2010
$845k
NEI NIH HHS EY019478-01NEI NIH HHS EY09339NEI NIH HHS R01 EY009339NEI NIH HHS T32 EY007157NEI NIH HHS T32EY007157NIGMS NIH HHS GM079191NIGMS NIH HHS R01 GM079191NIGMS NIH HHS T32 GM007250NIGMS NIH HHS T32-GM007250
6 · The paper itself

Abstract

Although outnumbered more than 20:1 by rod photoreceptors, cone cells in the human retina mediate daylight vision and are critical for visual acuity and color discrimination. A variety of human diseases are characterized by a progressive loss of cone photoreceptors but the low abundance of cones and the absence of a macula in non-primate mammalian retinas have made it difficult to investigate cones directly. Conventional rodents (laboratory mice and rats) are nocturnal rod-dominated species with few cones in the retina, and studying other animals with cone-rich retinas presents various logistic and technical difficulties. Originating in the early 1900s, past research has begun to provide insights into cone ultrastructure but has yet to afford an overall perspective of cone cell organization. This review summarizes our past progress and focuses on the recent introduction of special mammalian models (transgenic mice and diurnal rats rich in cones) that together with new investigative techniques such as atomic force microscopy and cryo-electron tomography promise to reveal a more unified concept of cone photoreceptor organization and its role in retinal diseases.

Indexed as

AnimalsElectron Microscope TomographyHumansMiceMice, TransgenicMicroscopy, Atomic ForceModels, AnimalRatsRetinal Cone Photoreceptor CellsRetinal DiseasesRetinal Rod Photoreceptor CellsVision, Ocular

Identifiers

PMID19501669
PMCPMC2740621
OpenAlexW2153150479

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.