ArticleNeuroscience2009
The encoding of cocaine vs. natural rewards in the striatum of nonhuman primates: categories with different activations.
Article in Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Drug-Related Engrams and Their Role in the Persistence and Recurrence of Drug-Related Behaviors.Hippocampus · 2025Review
- Simultaneous Voltammetric Measurements of Glucose and Dopamine Demonstrate the Coupling of Glucose Availability with Increased Metabolic Demand in the Rat Striatum.ACS chemical neuroscience · 2017Article
- Mechanistic Resolution Required to Mediate Operant Learned Behaviors: Insights from Neuronal Ensemble-Specific Inactivation.Frontiers in neural circuits · 2017Article
- Neostriatal Neuronal Activity Correlates Better with Movement Kinematics under Certain Rewards.Frontiers in neuroscience · 2016Article
- Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction.Brain research · 2015Review
- Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions.Annals of the New York Academy of Sciences · 2015Review
- Disruption of columnar and laminar cognitive processing in primate prefrontal cortex following cocaine exposure.Frontiers in systems neuroscience · 2015Article
- Prefrontal cortical minicolumn: from executive control to disrupted cognitive processing.Brain : a journal of neurology · 2014Review
- Role of nucleus accumbens shell neuronal ensembles in context-induced reinstatement of cocaine-seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Functional dynamics of primate cortico-striatal networks during volitional movements.Frontiers in systems neuroscience · 2014Article
- Facilitation of memory encoding in primate hippocampus by a neuroprosthesis that promotes task-specific neural firing.Journal of neural engineering · 2013Article
- The impact of self-reported life stress on current impulsivity in cocaine dependent adults.Progress in neuro-psychopharmacology & biological psychiatry · 2013Article
- Dorsolateral caudate nucleus differentiates cocaine from natural reward-associated contextual cues.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The temporal derivative of expected utility: a neural mechanism for dynamic decision-making.NeuroImage · 2013Article
- Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen.Psychopharmacology · 2013Article
- Columnar processing in primate pFC: evidence for executive control microcircuits.Journal of cognitive neuroscience · 2012Article
- Striatal volume increases in active methamphetamine-dependent individuals and correlation with cognitive performance.Brain sciences · 2012Article
- Facilitation and restoration of cognitive function in primate prefrontal cortex by a neuroprosthesis that utilizes minicolumn-specific neural firing.Journal of neural engineering · 2012Article
- Dynamic changes of tyrosine hydroxylase and dopamine concentrations in the ventral tegmental area-nucleus accumbens projection during the expression of morphine-induced conditioned place preference in rats.Neurochemical research · 2012Article
- A novel tetrode microdrive for simultaneous multi-neuron recording from different regions of primate brain.Journal of neuroscience methods · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The behavioral and motivational changes that result from use of abused substances depend upon activation of neuronal populations in the reward centers of the brain, located primarily in the corpus striatum in primates. To gain insight into the cellular mechanisms through which abused drugs reinforce behavior in the primate brain, changes in firing of neurons in the ventral (VStr, nucleus accumbens) and dorsal (DStr, caudate-putamen) striatum to "natural" (juice) vs. drug (i.v. cocaine) rewards were examined in four rhesus monkeys performing a visual Go-Nogo decision task. Task-related striatal neurons increased firing to one or more of the specific events that occurred within a trial represented by (1) Target stimuli (Go trials) or (2) Nogotarget stimuli (Nogo trials), and (3) Reward delivery for correct performance. These three cell populations were further subdivided into categories that reflected firing exclusively on one or the other type of signaled reward (juice or cocaine) trial (20%-30% of all cells), or, a second subpopulation that fired on both (cocaine and juice) types of rewarded trial (50%). Results show that neurons in the primate striatum encoded cocaine-rewarded trials similar to juice-rewarded trials, except for (1) increased firing on cocaine-rewarded trials, (2) prolonged activation during delivery of i.v. cocaine infusion, and (3) differential firing in ventral (VStr cells) vs. dorsal (DStr cells) striatum cocaine-rewarded trials. Reciprocal activations of antithetic subpopulations of cells during different temporal intervals within the same trial suggest a functional interaction between processes that encode drug and natural rewards in the primate brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.