ReviewBiochimica et biophysica acta
RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs.
Review in Biochimica et biophysica acta. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Decoding the Structural Complexity of Viral RNAs with SHAPE to Guide Antiviral Therapeutics.Viruses · 2026Review
- Conformational Dynamics of the RNA G-Quadruplex and its Effect on Translation Efficiency.Molecules (Basel, Switzerland) · 2019Article
- RNA Structural Differentiation: Opportunities with Pattern Recognition.Biochemistry · 2019Review
- Article
- Characterization and visualization of RNA secondary structure Boltzmann ensemble via information theory.BMC bioinformatics · 2018Article
- Article
- An RNA Element That Facilitates Programmed Ribosomal Readthrough in Turnip Crinkle Virus Adopts Multiple Conformations.Journal of virology · 2016Article
- Single-Molecule FRET Reveals Three Conformations for the TLS Domain of Brome Mosaic Virus Genome.Biophysical journal · 2015Article
- Revealing the density of encoded functions in a viral RNA.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Molecular characterization of a bipartite double-stranded RNA virus and its satellite-like RNA co-infecting the phytopathogenic fungus Sclerotinia sclerotiorum.Frontiers in microbiology · 2015Article
- Evidence of pervasive biologically functional secondary structures within the genomes of eukaryotic single-stranded DNA viruses.Journal of virology · 2014Article
- Physicochemical analysis of rotavirus segment 11 supports a 'modified panhandle' structure and not the predicted alternative tRNA-like structure (TRLS).Archives of virology · 2014Article
- The effect of gene overlapping on the rate of RNA virus evolution.Molecular biology and evolution · 2013Article
- Three-dimensional RNA structure of the major HIV-1 packaging signal region.Structure (London, England : 1993) · 2013Article
- Long-range architecture in a viral RNA genome.Biochemistry · 2013Article
- Evidence that viral RNAs have evolved for efficient, two-stage packaging.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A local, interactive network of 3' RNA elements supports translation and replication of Turnip crinkle virus.Journal of virology · 2012Article
- Predicting folding pathways between RNA conformational structures guided by RNA stacks.BMC bioinformatics · 2012Article
- Internal RNA Replication Elements are Prevalent in Tombusviridae.Frontiers in microbiology · 2012Article
- Multifaceted regulation of translational readthrough by RNA replication elements in a tombusvirus.PLoS pathogens · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The rugged nature of the RNA structural free energy landscape allows cellular RNAs to respond to environmental conditions or fluctuating levels of effector molecules by undergoing dynamic conformational changes that switch on or off activities such as catalysis, transcription or translation. Infectious RNAs must also temporally control incompatible activities and rapidly complete their life cycle before being targeted by cellular defenses. Viral genomic RNAs must switch between translation and replication, and untranslated subviral RNAs must control other activities such as RNA editing or self-cleavage. Unlike well characterized riboswitches in cellular RNAs, the control of infectious RNA activities by altering the configuration of functional RNA domains has only recently been recognized. In this review, we will present some of these molecular rearrangements found in RNA viruses, viroids and virus-associated RNAs, relating how these dynamic regions were discovered, the activities that might be regulated, and what factors or conditions might cause a switch between conformations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.