ArticleNeurobiology of disease2009
The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies.
Article in Neurobiology of disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Are high doses of carbidopa a concern? A randomized, clinical trial in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2012Trial
- HucMSCs-derived Exosomes Protect Against 6-hydroxydopamineinduced Parkinson's Disease in Rats by Inhibiting Caspase-3 Expression and Suppressing Apoptosis.Current stem cell research & therapy · 2025Article
- Blood-brain barrier alterations and their impact on Parkinson's disease pathogenesis and therapy.Translational neurodegeneration · 2024Review
- Article
- Microvascular Changes in Parkinson's Disease- Focus on the Neurovascular Unit.Frontiers in aging neuroscience · 2022Review
- Blood-brain barrier permeability in Parkinson's disease patients with and without dyskinesia.Journal of neurology · 2021Article
- Scaling behavior of drug transport and absorption in in silico cerebral capillary networks.PloS one · 2018Article
- Effects of levodopa on regional cerebral metabolism and blood flow.Movement disorders : official journal of the Movement Disorder Society · 2015Review
- Presynaptic Mechanisms of l-DOPA-Induced Dyskinesia: The Findings, the Debate, and the Therapeutic Implications.Frontiers in neurology · 2014Review
- Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons.Stem cells (Dayton, Ohio) · 2013Article
- Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease.Fluids and barriers of the CNS · 2012Article
- L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain.Parkinson's disease · 2012Article
- Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsy.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
- An angiogenic inhibitor, cyclic RGDfV, attenuates MPTP-induced dopamine neuron toxicity.Experimental neurology · 2011Article
- Vascular endothelial growth factor is upregulated by L-dopa in the parkinsonian brain: implications for the development of dyskinesia.Brain : a journal of neurology · 2011Article
- Development of histocompatible primate-induced pluripotent stem cells for neural transplantation.Stem cells (Dayton, Ohio) · 2011Article
- Striatal Signaling in L-DOPA-Induced Dyskinesia: Common Mechanisms with Drug Abuse and Long Term Memory Involving D1 Dopamine Receptor Stimulation.Frontiers in neuroanatomy · 2011Article
- Neuroinflammation in Parkinson's disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2009Review
- Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients.Journal of neurology · 2009Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
It has been suggested, based on rodent studies, that levodopa (L-dopa) induced dyskinesia is associated with a disrupted blood-brain barrier (BBB). We have investigated BBB integrity with in vivo neuroimaging techniques in six 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned primates exhibiting L-dopa-induced dyskinesia. Magnetic resonance imaging (MRI) performed before and after injection of Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) revealed an intact BBB in the basal ganglia showing that l-dopa-induced dyskinesia is not associated with a disrupted BBB in this model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.