ArticleDifferentiation; research in biological diversity2009
Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors.
Article in Differentiation; research in biological diversity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 78 citations in OpenAlex.
- A Comparative Analysis of the Genetic Structures of Rhesus Macaques (Macaca mulatta) Kept in Enclosure-Based Systems and Semi-Natural Settings.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Induced pluripotent stem cells derived renal tubular cells from a patient with pseudohypoparathyroidism and its response to parathyroid hormone stimulation.Molecular biology reports · 2024Article
- Multilineage-differentiating stress-enduring cells: a powerful tool for tissue damage repair.Frontiers in cell and developmental biology · 2024Review
- Promotion of Cyst Formation from a Renal Stem Cell Line Using Organ-Specific Extracellular Matrix Gel Format Culture System.Gels (Basel, Switzerland) · 2022Article
- Generation of Progesterone-Responsive Endometrial Stromal Fibroblasts from Human Induced Pluripotent Stem Cells: Role of the WNT/CTNNB1 Pathway.Stem cell reports · 2018Article
- Embryonic Stem Cells Derived Kidney Organoids as Faithful Models to Target Programmed Nephrogenesis.Scientific reports · 2018Article
- Renal lineage cells as a source for renal regeneration.Pediatric research · 2018Review
- Beneficial Effects of Systemically Administered Human Muse Cells in Adriamycin Nephropathy.Journal of the American Society of Nephrology : JASN · 2017Article
- Regenerative Medicine, Disease Modeling, and Drug Discovery in Human Pluripotent Stem Cell-derived Kidney Tissue.European Medical Journal. Reproductive health · 2017Article
- Generation of kidney tubular organoids from human pluripotent stem cells.Scientific reports · 2016Article
- Generation of functional podocytes from human induced pluripotent stem cells.Stem cell research · 2016Article
- Renal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury.Scientific reports · 2015Article
- Natural Scaffolds for Renal Differentiation of Human Embryonic Stem Cells for Kidney Tissue Engineering.PloS one · 2015Article
- Directed Differentiation of Pluripotent Stem Cells into Kidney.Biomarker insights · 2015Review
- Article
- The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells.Nature protocols · 2014Article
- Directed differentiation of pluripotent stem cells to kidney cells.Seminars in nephrology · 2014Review
- Bioengineering kidneys for transplantation.Seminars in nephrology · 2014Review
- Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.Journal of the American Society of Nephrology : JASN · 2014Article
- Bone morphogenetic protein signaling in nephron progenitor cells.Pediatric nephrology (Berlin, Germany) · 2014Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The development of the metanephric kidney was studied immunohistochemically across gestation in monkeys to identify markers of cell specification, and to aid in developing experimental paradigms for renal precursor differentiation from human embryonic stem cells (hESC). PAX2, an important kidney developmental marker, was expressed at the tips of the ureteric bud, in the surrounding condensing mesenchyme, and in the renal vesicle. Vimentin, a mesenchymal and renal marker, was strongly expressed in the metanephric blastema then found to be limited to the glomerulus and interstitial cells of the medulla and cortex. A model of gene expression based on human and nonhuman primate renal ontogeny was developed and incorporated into studies of hESC differentiation. Spontaneous hESC differentiation revealed markers of metanephric mesenchyme (OSR1, PAX2, SIX2, WT1) that increased over time, followed by upregulation of kidney precursor markers (EYA1, LIM1, CD24). Directed hESC differentiation was also evaluated with the addition of retinoic acid, Activin-A, and BMP-4 or BMP-7, and using different culture substrate conditions. Of the culture substrates studied, gelatin most closely recapitulated the anticipated directed developmental pattern of renal gene expression. No differences were found when BMP-4 and BMP-7 were compared with baseline conditions. PAX2 and Vimentin immunoreactivity in differentiating hESC was also similar to the renal precursor patterns reported for human fetal kidneys and findings described in rhesus monkeys. The results of these studies are as follows: (1) provide additional data to support that rhesus monkey kidney development parallels that of humans, and (2) provide a useful model for hESC directed differentiation towards renal precursors.
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