ArticleAmerican journal of human genetics2009
Mitochondrial haplogroup U5b3: a distant echo of the epipaleolithic in Italy and the legacy of the early Sardinians.
Article in American journal of human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Fifteen millennia of human mitogenome evolution in Sicily.Science advances · 2025Article
- Whole mitogenomes reveal that NW Africa has acted both as a source and a destination for multiple human movements.Scientific reports · 2023Article
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- Evolution and dispersal of mitochondrial DNA haplogroup U5 in Northern Europe: insights from an unsupervised learning approach to phylogeography.BMC genomics · 2022Article
- The forensic landscape and the population genetic analyses of Hainan Li based on massively parallel sequencing DNA profiling.International journal of legal medicine · 2021Article
- Y-chromosome and Surname Analyses for Reconstructing Past Population Structures: The Sardinian Population as a Test Case.International journal of molecular sciences · 2019Article
- Ancient DNA of Phoenician remains indicates discontinuity in the settlement history of Ibiza.Scientific reports · 2018Article
- Genomic history of the Sardinian population.Nature genetics · 2018Article
- A finely resolved phylogeny of Y chromosome Hg J illuminates the processes of Phoenician and Greek colonizations in the Mediterranean.Scientific reports · 2018Article
- Mitogenome Diversity in Sardinians: A Genetic Window onto an Island's Past.Molecular biology and evolution · 2017Article
- Complex interplay between neutral and adaptive evolution shaped differential genomic background and disease susceptibility along the Italian peninsula.Scientific reports · 2016Article
- Fine Dissection of Human Mitochondrial DNA Haplogroup HV Lineages Reveals Paleolithic Signatures from European Glacial Refugia.PloS one · 2015Article
- Article
- Ancient DNA reveals prehistoric gene-flow from siberia in the complex human population history of North East Europe.PLoS genetics · 2013Article
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- Introducing the Algerian mitochondrial DNA and Y-chromosome profiles into the North African landscape.PloS one · 2013Article
- Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata.PloS one · 2013Article
- Article
- Dissecting the genetic make-up of North-East Sardinia using a large set of haploid and autosomal markers.European journal of human genetics : EJHG · 2012Article
- Bulgarians vs the other European populations: a mitochondrial DNA perspective.International journal of legal medicine · 2012Article
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26 authors.
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Abstract
There are extensive data indicating that some glacial refuge zones of southern Europe (Franco-Cantabria, Balkans, and Ukraine) were major genetic sources for the human recolonization of the continent at the beginning of the Holocene. Intriguingly, there is no genetic evidence that the refuge area located in the Italian Peninsula contributed to this process. Here we show, through phylogeographic analyses of mitochondrial DNA (mtDNA) variation performed at the highest level of molecular resolution (52 entire mitochondrial genomes), that the most likely homeland for U5b3-a haplogroup present at a very low frequency across Europe-was the Italian Peninsula. In contrast to mtDNA haplogroups that expanded from other refugia, the Holocene expansion of haplogroup U5b3 toward the North was restricted by the Alps and occurred only along the Mediterranean coasts, mainly toward nearby Provence (southern France). From there, approximately 7,000-9,000 years ago, a subclade of this haplogroup moved to Sardinia, possibly as a result of the obsidian trade that linked the two regions, leaving a distinctive signature in the modern people of the island. This scenario strikingly matches the age, distribution, and postulated geographic source of a Sardinian Y chromosome haplogroup (I2a2-M26), a paradigmatic case in the European context of a founder event marking both female and male lineages.
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